Grollman E F, Lee G, Ramos S, Lazo P S, Kaback H R, Friedman R M, Kohn L D
Cancer Res. 1978 Nov;38(11 Pt 2):4172-85.
This report describes similarities between the structure and function of the interferon receptor and receptors for glycoprotein hormones and several bacterial toxins. Specifically, it describes several common molecular and mechanistic elements, including: (a) the presence of a glycoprotein as well as a ganglioside component in the receptor; (b) changes in membrane structure as a consequence of interferon action; (c) interferon-induced intracellular cyclic adenosine 3':5'-monophosphate changes; and (d) alterations in the flux of certain ions across the membrane. Since interferon has an antiviral effect, these results define a relationship between hormonal perturbation of cellular events and the ability of an agent to prevent or suppress viral infections of cells. Further definition of these relationships should be important to our understanding of the oncogenic state, of hormonal effects on the oncogenic state, and of other human diseases in which hormonal perturbations of non-target tissues or cross-reactivity of receptors could be pathogenic.
本报告描述了干扰素受体与糖蛋白激素受体及几种细菌毒素受体在结构和功能上的相似性。具体而言，它描述了几个共同的分子和机制要素，包括：(a)受体中存在糖蛋白以及神经节苷脂成分；(b)干扰素作用导致的膜结构变化；(c)干扰素诱导的细胞内3':5'-环磷酸腺苷变化；以及(d)某些离子跨膜通量的改变。由于干扰素具有抗病毒作用，这些结果确定了细胞事件的激素扰动与一种物质预防或抑制细胞病毒感染能力之间的关系。对这些关系的进一步明确对于我们理解致癌状态、激素对致癌状态的影响以及其他非靶组织的激素扰动或受体交叉反应可能致病的人类疾病具有重要意义。
