Filipiĉ B, Schauer P, Likar M
Arch Immunol Ther Exp (Warsz). 1977;25(5):613-8.
Cellular receptors are molecules located on the cell membrane. Their function is to bind different molecules to the cell surface. These molecules can penetrate into the cytoplasm and trigger cellular changes. One kind of such bound molecules are interferons and corticosteroids. Until very recently very little was known about interferon's receptors on the cell surface, mechanisms of interferon's binding to them or about kinetics of such binding. On the basis of results published elsewhere and on the basis of experimental results, the authors suggest: 1) receptors for interferon and cortisol are glycoproteins located on the cell surface, 2) in analogy with PHA receptors they are chemically sialoglycoproteins, 3) binding kinetics of cortisol and interferon is similar, 4) interferon and cortisol compete for cellular receptors, 5) binding of cortisol or interferon is dependent on allosteric configuration of receptor molecules.
细胞受体是位于细胞膜上的分子。它们的功能是将不同分子结合到细胞表面。这些分子能够渗透到细胞质中并引发细胞变化。一类这样的结合分子是干扰素和皮质类固醇。直到最近，人们对细胞表面的干扰素受体、干扰素与它们的结合机制或这种结合的动力学了解甚少。基于其他地方发表的结果以及实验结果，作者提出：1）干扰素和皮质醇的受体是位于细胞表面的糖蛋白，2）与PHA受体类似，它们是化学唾液酸糖蛋白，3）皮质醇和干扰素的结合动力学相似，4）干扰素和皮质醇竞争细胞受体，5）皮质醇或干扰素的结合取决于受体分子的别构构型。
