Expression and Clinical Significance of and in Triple-Negative Breast Cancer.

The CKLF-like MARVEL transmembrane domain containing 6 () plays an extremely important role of the programed death receptor ligand-1 () protein. Our study is aimed at investigating the expression of and proteins in triple-negative breast cancer and their correlation with the clinical pathological data of patients. We selected 89 cases of triple-negative breast cancer and 62 cases of normal breast tissue specimens. Immunohistochemical methods were used to detect the expression levels of and and to carefully study differences in their expression. The expression of and in TNBC was higher than that in normal breast tissue, and the expression of the two was positively correlated ( < 0.05). In TNBC, expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, and TNM stage ( < 0.05). expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, TNM stage, and vascular infiltration ( < 0.05). Kaplan-Meier analysis showed that the positive expression of and had no correlation with the survival rate of patients ( > 0.05). According to KM-plotter, we found that a higher CMTM6 expression was positively related with relapse-free survival rate of patients ( < 0.05). A higher PD-L1 expression was positively correlated with relapse-free, overall, and distant metastasis survival rate of patients ( < 0.05). In timer database, we found a positive correlation between the expression of CMTM6 and PD-L1 in triple-negative breast cancer. Both and are highly expressed in TNBC, and their expressions are positively related. In the future, the two gene might become targets for the treatment of TNBC, providing a basis of clinical treatment of TNBC.