State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Front Endocrinol (Lausanne). 2022 Jun 29;13:884851. doi: 10.3389/fendo.2022.884851. eCollection 2022.
Adequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative women.
The present study was conducted within the Jiangsu Birth Cohort. A total of 793 mother-infant pairs were eligible for the present study. Maternal thyroid function was assessed by measuring serum thyroid-stimulating hormone, free thyroxine, and thyroid peroxidase antibodies. Neurodevelopment of infants was assessed by using the Bayley Scales of Infant and Toddler Development third edition screening test (Bayley-III screening test).
In the multivariate adjusted linear regression analyses, infants of women with subclinical hypothyroidism and isolated hypothyroxinemia were associated with decreased receptive communication scores ( = -0.68, = 0.034) and decreased gross motor scores ( = -0.83, = 0.008), respectively. Moreover, infants of women with high-normal TSH concentrations (3.0-4.0 mIU/L) and low FT4 concentrations were significantly associated with lower gross motor scores ( = -1.19, = 0.032), while no differences were observed in infants when the mothers had a high-normal TSH concentration and normal FT4 levels.
Maternal subclinical hypothyroidism is associated with decreased receptive communication scores in infants at 1 year of age. In addition, maternal TSH concentration greater than 4.0 mIU/L and maternal isolated hypothyroxinemia are associated with impaired gross motor ability of infants, especially in infants of women with high-normal TSH concentrations (3.0-4.0 mIU/L).
充足的母体甲状腺激素供应对胎儿神经发育至关重要，但母体轻度甲状腺功能减退的作用尚不清楚。我们旨在研究 TPOAb 阴性妇女中，母体轻度甲状腺功能减退与婴儿 1 岁时神经发育的关系。
本研究在江苏省出生队列中进行。共有 793 对母婴符合本研究条件。通过测量血清促甲状腺激素、游离甲状腺素和甲状腺过氧化物酶抗体来评估母体甲状腺功能。使用贝利婴幼儿发展量表第三版筛查测验（贝利-III 筛查测验）评估婴儿的神经发育。
在多变量调整的线性回归分析中，亚临床甲状腺功能减退症和单纯甲状腺素血症妇女的婴儿与接受性沟通评分降低（ = -0.68， = 0.034）和粗大运动评分降低（ = -0.83， = 0.008）相关。此外，高正常 TSH 浓度（3.0-4.0 mIU/L）和低 FT4 浓度的妇女的婴儿与较低的粗大运动评分显著相关（ = -1.19， = 0.032），而当母亲 TSH 浓度高正常但 FT4 水平正常时，婴儿没有差异。
母体亚临床甲状腺功能减退与婴儿 1 岁时的接受性沟通评分降低有关。此外，TSH 浓度大于 4.0 mIU/L 和单纯甲状腺素血症与婴儿粗大运动能力受损有关，尤其是在 TSH 浓度高正常（3.0-4.0 mIU/L）的妇女的婴儿中。
