Jacques P F, Hartz S C, McGandy R B, Jacob R A, Russell R M
J Am Coll Nutr. 1987 Apr;6(2):169-74. doi: 10.1080/07315724.1987.10720177.
The relationships between ascorbic acid (plasma and dietary) and plasma HDL cholesterol (HDL-C), total plasma cholesterol (T-C) and T-C:HDL-C ratio were examined in a population of 235 males and 445 females, age 60-98 years. Many known or suspected determinants of HDL-C and T-C, including age, sex, triceps skinfold thickness, fasting blood glucose, alcohol intake, and others, were considered as covariates due to their potential confounding or modifying effects on the relationships under study. The results show that plasma ascorbic acid is significantly (p less than 0.05) correlated with HDL-C (r = 0.09), T-C:HDL-C (r = 0.10), but not with T-C (r = 0.03). There is a strong age interaction with the largest effect of ascorbic acid in the youngest age group studied (60-69 years). The effects of dietary ascorbic acid are similar but slightly reduced in magnitude.
在235名男性和445名年龄在60至98岁之间的女性群体中，研究了血浆和膳食中的抗坏血酸与血浆高密度脂蛋白胆固醇（HDL-C）、总血浆胆固醇（T-C）以及T-C:HDL-C比值之间的关系。许多已知或疑似的HDL-C和T-C的决定因素，包括年龄、性别、肱三头肌皮褶厚度、空腹血糖、酒精摄入量等，因其对所研究关系可能存在的混杂或调节作用而被视为协变量。结果显示，血浆抗坏血酸与HDL-C（r = 0.09）、T-C:HDL-C（r = 0.10）显著相关（p小于0.05），但与T-C（r = 0.03）无显著相关性。在所研究的最年轻年龄组（60 - 69岁）中，抗坏血酸的作用与年龄存在强烈的相互作用，影响最大。膳食抗坏血酸的作用相似，但程度略有降低。
