Darand Mina, Salehi-Abargouei Amin, Vahidi Mehrjardi Mohammad Yahya, Feizi Awat, Seyedhossaini Seyed Mustafa, Askari Gholamreza
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Front Nutr. 2023 Feb 2;9:1097411. doi: 10.3389/fnut.2022.1097411. eCollection 2022.
Considering the emergence of the concept of personalized nutrition in recent years and its importance in the treatment of diseases, the purpose of this study was to investigate the interaction of paraoxonase (PON)1 rs662 polymorphism and vitamin C/E intake on coronary artery disease (CAD) severity and lipid profile in patients undergoing diagnostic angiography.
This cross-sectional study was carried out on 428 patients undergoing angiography. The PON-1 genotypes were detected by the polymerase chain reaction-restriction fragment length polymorphism technique. Dietary intake was obtained using a valid questionnaire.
After adjustment for potential confounders, R allele carriers (RR + RQ) have lower HDL-C levels than non-carriers (QQ) ( ≤ 0.05). On the other hand, higher consumption of vitamin C was associated with a reduced risk of high total cholesterol (OR: 0.42, 95% CI 0.23-0.75, = 0.003) and low-density lipoprotein cholesterol (OR: 0.49, 95% CI 0.25-0.96, = 0.038) and an increased risk of low high-density lipoprotein cholesterol (OR: 1.88, 95% CI 1.03-3.42, = 0.037). Furthermore, a significant interaction was observed between vitamin C intake and genotypes of rs66 polymorphism on LDL-C ( = 0.050). In detail, the R-allele carriers with lower vitamin C intake had higher LDL-C levels than QQ genotype carriers. No significant interaction was found between vitamin E intake and rs662 polymorphism genotypes on the Gensini and SYNTAX scores and lipid profile ( > 0.05).
The novel finding of the present study was the existence of a significant interaction between rs662 polymorphism and vitamin C intake on LDL-C. More specifically, R allele carriers with lower vitamin C intake were susceptible to higher LDL-C.
鉴于近年来个性化营养概念的出现及其在疾病治疗中的重要性，本研究旨在探讨对氧磷酶（PON）1 rs662多态性与维生素C/E摄入量对接受诊断性血管造影患者的冠状动脉疾病（CAD）严重程度和血脂谱的相互作用。
本横断面研究对428例接受血管造影的患者进行。采用聚合酶链反应-限制性片段长度多态性技术检测PON-1基因型。通过有效的问卷获取饮食摄入量。
在对潜在混杂因素进行调整后，R等位基因携带者（RR + RQ）的高密度脂蛋白胆固醇（HDL-C）水平低于非携带者（QQ）（P≤0.05）。另一方面，较高的维生素C摄入量与高总胆固醇风险降低（比值比：0.42，95%置信区间0.23 - 0.75，P = 0.003）、低密度脂蛋白胆固醇降低（比值比：0.49，95%置信区间0.25 - 0.96，P = 0.038）以及低高密度脂蛋白胆固醇风险增加（比值比：1.88，95%置信区间1.03 - 3.42，P = 0.037）相关。此外，观察到维生素C摄入量与rs66多态性基因型在低密度脂蛋白胆固醇方面存在显著相互作用（P = 0.050）。具体而言，维生素C摄入量较低的R等位基因携带者的低密度脂蛋白胆固醇水平高于QQ基因型携带者。在Gensini和SYNTAX评分及血脂谱方面，未发现维生素E摄入量与rs662多态性基因型之间存在显著相互作用（P>0.05）。
本研究的新发现是rs662多态性与维生素C摄入量在低密度脂蛋白胆固醇方面存在显著相互作用。更具体地说，维生素C摄入量较低的R等位基因携带者易患较高的低密度脂蛋白胆固醇。
