Barbee R A, Halonen M, Kaltenborn W, Lebowitz M, Burrows B
J Allergy Clin Immunol. 1987 Jun;79(6):919-27. doi: 10.1016/0091-6749(87)90241-7.
A number of factors, including age, sex, smoking habits, and atopic status have been reported in cross-sectional studies to influence levels of serum IgE. We have examined the effects of these variables on serum IgE in a community population cohort of 1109 subjects during a longitudinal study in which two serum samples were obtained 8 years apart from each subject. For the entire cohort, mean serum IgE level changed little during the follow-up period (28.9 versus 26.0 IU/ml). Most of the decreases were observed in children and young adults. Subjects more than the age of 35 years demonstrated no systematic change in serum IgE levels. By the end of follow-up (when there were few subjects still less than 16 years of age), significant relationships of IgE to age could no longer be demonstrated in nonatopic subjects. Also, in the nonatopic subjects of this cohort, there were no significant differences in IgE levels between the sexes. Among atopic subjects, there was a clear tendency for IgE to decrease with age, with atopic women more than 35 years of age demonstrating greater declines in IgE levels during follow-up than men of comparable age. The IgE levels in atopic male subjects were significantly higher than in atopic female subjects after the age of 35 years. Smoking was associated with an elevation in serum IgE. In this cohort, the smoking effect appeared to be limited to male subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
在横断面研究中，已报道包括年龄、性别、吸烟习惯和特应性状态在内的多种因素会影响血清IgE水平。在一项针对1109名受试者的社区人群队列纵向研究中，我们研究了这些变量对血清IgE的影响，该研究中每位受试者相隔8年采集两份血清样本。对于整个队列，随访期间血清IgE平均水平变化不大（28.9与26.0 IU/ml）。大多数下降情况出现在儿童和年轻人中。35岁以上的受试者血清IgE水平未显示出系统性变化。到随访结束时（当时年龄小于16岁的受试者已很少），在非特应性受试者中IgE与年龄之间的显著关系已无法显示。此外，在该队列的非特应性受试者中，两性之间的IgE水平无显著差异。在特应性受试者中，IgE有随年龄下降的明显趋势，35岁以上的特应性女性在随访期间IgE水平的下降幅度大于同龄男性。35岁以后，特应性男性受试者的IgE水平显著高于特应性女性受试者。吸烟与血清IgE升高有关。在该队列中，吸烟的影响似乎仅限于男性受试者。（摘要截短于250字）
