Sherrill D L, Halonen M, Burrows B
Respiratory Sciences Center, University of Arizona, College of Medicine, Tucson 85724.
J Allergy Clin Immunol. 1994 Dec;94(6 Pt 1):954-62. doi: 10.1016/0091-6749(94)90113-9.
A number of cross-sectional studies have demonstrated that higher levels of IgE are found in subjects who currently smoke cigarettes and/or who are atopic and that IgE levels decline with age.
This report examines the interactions among atopic status, smoking, and IgE with longitudinal data and methods.
Subjects were participants in the Tucson Epidemiological Study of Airways Obstructive Disease and were 6 years of age and older. Total serum IgE measures and allergen skin test results were obtained during three surveys spanning a period of up to 20 years.
The results showed no significant gender differences between nonatopic nonsmoking subjects, who were considered the reference group. Nonatopic current smokers had IgE levels similar to those of the reference subjects initially, but IgE levels did not decline with age at the same rate as in the reference subjects, causing significant differences at older ages. There was a significant relationship between number of cigarettes smoked and IgE level.
Atopy and smoking are both associated with elevated total serum IgE levels. Although the exact mechanism for elevated IgE levels in smokers is not known, the significant dose relationship is suggestive of a causal association.
多项横断面研究表明，目前吸烟和/或患有特应性疾病的受试者体内的IgE水平较高，且IgE水平会随年龄下降。
本报告采用纵向数据和方法研究特应性状态、吸烟和IgE之间的相互作用。
研究对象为图森气道阻塞性疾病流行病学研究的参与者，年龄在6岁及以上。在长达20年的三次调查中获取了总血清IgE测量值和过敏原皮肤试验结果。
结果显示，以非特应性不吸烟受试者作为参照组，其IgE水平无显著性别差异。非特应性现吸烟者最初的IgE水平与参照组相似，但IgE水平随年龄下降的速度与参照组不同，导致在老年时出现显著差异。吸烟量与IgE水平之间存在显著关系。
特应性和吸烟均与总血清IgE水平升高有关。虽然吸烟者IgE水平升高的确切机制尚不清楚，但显著的剂量关系提示存在因果关联。
