College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing 100193, China.
Int J Mol Sci. 2021 Oct 28;22(21):11708. doi: 10.3390/ijms222111708.
Selenium (Se) is an essential trace element in the body. It is mainly used in the body in the form of selenoproteins and has a variety of biological functions. Intestinal diseases caused by chronic inflammation are among the most important threats to human health, and there is no complete cure at present. Due to its excellent antioxidant function, Se has been proven to be effective in alleviating intestinal diseases such as inflammatory bowel diseases (IBDs). Therefore, this paper introduces the role of Se and selenoproteins in the intestinal tract and the mechanism of their involvement in the mediation of intestinal diseases. In addition, it introduces the advantages and disadvantages of nano-Se as a new Se preparation and traditional Se supplement in the prevention and treatment of intestinal diseases, so as to provide a reference for the further exploration of the interaction between selenium and intestinal health.
硒(Se)是人体必需的微量元素。它主要以硒蛋白的形式在体内使用,具有多种生物学功能。由慢性炎症引起的肠道疾病是对人类健康最重要的威胁之一,目前尚无完全治愈的方法。由于其出色的抗氧化功能,硒已被证明可有效缓解炎症性肠病(IBD)等肠道疾病。因此,本文介绍了 Se 和硒蛋白在肠道中的作用及其在介导肠道疾病中的作用机制。此外,它还介绍了纳米硒作为一种新的 Se 制剂和传统 Se 补充剂在预防和治疗肠道疾病方面的优缺点,为进一步探索硒与肠道健康之间的相互作用提供了参考。