Mun-H-Center, Orofacial Resource Centre for Rare Diseases, Public Dental Service, Medicinaregatan, Gothenburg, Sweden.
J Neuromuscul Dis. 2022;9(5):581-596. doi: 10.3233/JND-210772.
BACKGROUND: The knowledge about the impact of oral motor impairment in neuromuscular diseases (NMDs) is limited but increasing. OBJECTIVE: The aim of this review was to collect and compile knowledge on how muscle weakness in congenital or early developing NMDs directly or indirectly affects feeding, swallowing, speech and saliva control. METHODS: A literature search was performed in PubMed from January 1, 1998, to August 31, 2021. The keywords "feeding", "dysphagia", "swallowing", "dysarthria", "speech", "drooling" and "sialorrhea" were used in combination with "paediatric neuromuscular disease" or specific diagnoses. RESULTS: Sixty-five studies were selected for the review, 33 focused on feeding and swallowing, 11 on speech, four on a combination of feeding, swallowing, saliva control or speech and 17 general descriptions. Most of the studies reported on patients with a disorder affecting muscles. These studies show that muscle weakness and impaired motility affecting the muscles innervated by the cranial nerves may influence feeding, swallowing, and speech, and that respiratory function, general health and neurodevelopmental delay also influence these functions. Feeding impairment and breathing difficulties are common in NMDs. Lifesaving interventions such as tube feeding and ventilatory support are common in severe cases. CONCLUSIONS: Feeding impairment, dysphagia and dysarthria are prevalent in NMDs with congenital or early age of onset. Feeding and swallowing has been studied more than speech and saliva control. More children with NMD survive thanks to new treatment options and it is therefore urgent to follow up how these therapies may impact the development of feeding, swallowing, and speech.
背景:关于神经肌肉疾病(NMD)中口腔运动障碍的影响的知识有限,但在不断增加。
目的:本综述的目的是收集和整理关于先天性或早期发病的 NMD 中肌肉无力如何直接或间接影响喂养、吞咽、言语和唾液控制的知识。
方法:在 PubMed 上进行了文献检索,检索时间为 1998 年 1 月 1 日至 2021 年 8 月 31 日。使用了“feeding”、“dysphagia”、“swallowing”、“dysarthria”、“speech”、“drooling”和“sialorrhea”等关键词,并与“pediatric neuromuscular disease”或特定诊断相结合。
结果:选择了 65 篇研究进行综述,其中 33 篇专注于喂养和吞咽,11 篇专注于言语,4 篇涉及喂养、吞咽、唾液控制或言语的综合描述,17 篇为一般描述。大多数研究报告的是影响肌肉的疾病患者。这些研究表明,影响颅神经支配的肌肉的肌肉无力和运动障碍可能会影响喂养、吞咽和言语,呼吸功能、整体健康和神经发育迟缓也会影响这些功能。喂养障碍和呼吸困难在 NMD 中很常见。在严重的情况下,救命干预措施如管饲和通气支持很常见。
结论:先天性或早期发病的 NMD 中,喂养障碍、吞咽困难和构音障碍很常见。与唾液控制相比,喂养和吞咽的研究更多。由于新的治疗选择,更多患有 NMD 的儿童得以存活,因此迫切需要跟踪这些疗法如何影响喂养、吞咽和言语的发展。
J Neuromuscul Dis. 2020
Folia Phoniatr Logop. 2004
Tremor Other Hyperkinet Mov (N Y). 2017-9-21
Ear Nose Throat J. 2018-3
Laryngoscope Investig Otolaryngol. 2025-2-25
Am J Speech Lang Pathol. 2021-5-18
Qual Health Res. 2021-7
N Engl J Med. 2021-3-11
Clin Nutr. 2021-6
Neuromuscul Disord. 2021-2
Neurology. 2021-3-9