Department of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Department of Hypertension, The Cardinal Stefan Wyszynski National Institute of Cardiology, Warsaw, Poland.
Nucl Med Rev Cent East Eur. 2022;25(2):119-126. doi: 10.5603/NMR.a2022.0025. Epub 2022 Jul 18.
Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is a well-established diagnostic approach for patients with suspected or confirmed coronary artery disease (CAD). In the present century, nuclear cardiology has benefited immensely from advances in imaging instrumentation and technology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient cadmium-zinc-telluride (CZT) detectors, collimators, and system designs have evolved as a result of the expansion of nuclear cardiology. A vast amount of evidence is emerging, demonstrating the new technology's advantages over the traditional gamma cameras. Myocardial perfusion imaging (MPI) using gamma-cameras with CZT detectors may be performed with the limited injected activity of radiotracer and recorded times. The use of CZT's dynamic acquisition of myocardial perfusion imaging in clinical practice may help cardiologists in detecting hemodynamically significant CAD. In this article, we present the current state of knowledge on cardiac CZT-SPECT scanners, a summary of the literature published on validation studies, radiation dose reduction, and dynamic acquisition, as well as a comparison of conventional myocardial perfusion imaging with invasive coronary angiography.
单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）是一种用于疑似或确诊冠心病（CAD）患者的成熟诊断方法。在本世纪，核医学得益于成像仪器和技术的进步而受益匪浅。专用心脏 SPECT 相机结合了新型、高效的碲化镉锌（CZT）探测器、准直器和系统设计，这是核医学发展的结果。大量证据表明，新技术在许多方面优于传统的伽马相机。使用带有 CZT 探测器的伽玛相机进行 MPI 可能需要使用放射性示踪剂的有限注入活性和记录时间。在临床实践中使用 CZT 的心肌灌注成像动态采集可能有助于心脏病专家检测血流动力学意义重大的 CAD。本文介绍了心脏 CZT-SPECT 扫描仪的最新知识，总结了有关验证研究、辐射剂量降低和动态采集的文献，以及与有创冠状动脉造影的常规心肌灌注成像的比较。
