Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine, Renji Hospital, Shanghai, China.
J Dig Dis. 2012 May;13(5):244-51. doi: 10.1111/j.1751-2980.2012.00587.x.
To provide a meta-analyisis on whether obesity could be a prognostic indicator on the severity, development of complications and mortality of acute pancreatitis (AP).
Eligible articles were retrieved using electronic databases. Clinical studies evaluating the association between obesity and disease course of patients with AP were included. Weighted mean difference (WMD) and 95% confidence interval (CI) were estimated and pooled using RevMan 4.2.8.
In all, 12 clinical studies with a total of 1483 patients were included in the analysis. Obese patients had a significantly increased risk of severe acute pancreatitis (SAP; RR=2.20, 95% CI 1.82-2.66, P<0.05), local complication (RR=2.68, 95% CI 2.09-3.43, P<0.05), systemic complication (RR=2.14, 95% CI 1.42-3.21, P<0.05) and in-hospital mortality (RR=2.59, 95% CI 1.66-4.03, P<0.05) compared with non-obese patients.
Obesity is a definite risk factor of morbidity and in-hospital mortality for AP and may serve as a prognostic indicator.
对肥胖是否可以作为急性胰腺炎（AP）严重程度、并发症发展和死亡率的预后指标进行荟萃分析。
使用电子数据库检索合格的文章。纳入评估肥胖与 AP 患者疾病过程之间关联的临床研究。使用 RevMan 4.2.8 估计和汇总加权均数差（WMD）和 95%置信区间（CI）。
共有 12 项临床研究纳入了总共 1483 名患者进行分析。肥胖患者患重症急性胰腺炎（SAP；RR=2.20，95%CI 1.82-2.66，P<0.05）、局部并发症（RR=2.68，95%CI 2.09-3.43，P<0.05）、全身并发症（RR=2.14，95%CI 1.42-3.21，P<0.05）和住院死亡率（RR=2.59，95%CI 1.66-4.03，P<0.05）的风险显著增加。
肥胖是 AP 发病率和住院死亡率的明确危险因素，可作为预后指标。
