Mitrolia Bobby, Swami Rampartap, Dadhich Piyush, Dadhich Sunil K, Chaudhary Sewaram, Hussain Sabir, Bhati Rajendra, Yadav Abhishek, Saini Vivek
Department of Gastroenterology, Dr. Sampurnanand Medical College, Jodhpur 342 003, India.
Indian J Gastroenterol. 2025 Sep 12. doi: 10.1007/s12664-025-01849-6.
Acute pancreatitis (AP) is a common gastrointestinal emergency with variable clinical course. Early identification of severe AP (SAP) is crucial for optimizing patient management. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been implicated in various metabolic disorders, but its role in predicting AP severity remains underexplored.
In this single-center, prospective study, 138 patients diagnosed with AP were enrolled between January 2022 and December 2024. The severity of AP was classified as per the Revised Atlanta Classification. TyG index was calculated at admission and compared with established severity scores, including the computed tomography severity index (CTSI) and bedside index of severe acute pancreatitis (BISAP). Statistical analyses were performed to assess the correlation of TyG index with disease severity, hospital stay, intensive care unit (ICU) admission and mortality.
Among the enrolled patients, 17% developed SAP. The mean TyG index was significantly higher in the SAP group compared to the non-SAP group (5.01 ± 0.33 vs. 4.69 ± 0.22, p < 0.001). Higher TyG index values correlated with prolonged hospital stay (p = 0.009), increased ICU admissions (p < 0.001) and greater mortality (p = 0.004). The predictive accuracy of the TyG index for SAP, as assessed by the area under the curve (AUC), was 0.902, higher than BISAP 0.696 and CTSI 0.751.
The TyG index is a simple and accessible biomarker that correlates with AP severity and prognosis. Its predictive value is higher than BISAP and CTSI.
急性胰腺炎（AP）是一种常见的胃肠道急症，临床病程多变。早期识别重症急性胰腺炎（SAP）对于优化患者管理至关重要。甘油三酯-葡萄糖（TyG）指数作为胰岛素抵抗的替代指标，已被证实与多种代谢紊乱有关，但其在预测AP严重程度方面的作用仍未得到充分研究。
在这项单中心前瞻性研究中，2022年1月至2024年12月期间纳入了138例诊断为AP的患者。AP的严重程度根据修订的亚特兰大分类法进行分类。入院时计算TyG指数，并与既定的严重程度评分进行比较，包括计算机断层扫描严重程度指数（CTSI）和重症急性胰腺炎床边指数（BISAP）。进行统计分析以评估TyG指数与疾病严重程度、住院时间、重症监护病房（ICU）入住率和死亡率的相关性。
在纳入的患者中，17%发生了SAP。SAP组的平均TyG指数显著高于非SAP组（5.01±0.33 vs. 4.69±0.22，p<0.001）。较高的TyG指数值与住院时间延长（p=0.009）、ICU入住率增加（p<0.001）和死亡率升高（p=0.004）相关。通过曲线下面积（AUC）评估，TyG指数对SAP的预测准确性为0.902，高于BISAP的0.696和CTSI的0.751。
TyG指数是一种简单且易于获取的生物标志物，与AP的严重程度和预后相关。其预测价值高于BISAP和CTSI。
