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1064nm 拉曼光谱快速原位检测 L. 中的 THC 和 CBD。

Rapid In Situ Detection of THC and CBD in L. by 1064 nm Raman Spectroscopy.

机构信息

Department of Physics, University of Cagliari, S.p. no. 8 Km 0700, 09042 Monserrato, CA, Italy.

Scientific Investigation Department (RIS) of Cagliari, Via Ludovico Ariosto, 24, 09129 Cagliari, CA, Italy.

出版信息

Anal Chem. 2022 Jul 26;94(29):10435-10442. doi: 10.1021/acs.analchem.2c01629. Epub 2022 Jul 18.

DOI:10.1021/acs.analchem.2c01629
PMID:35848818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9330313/
Abstract

The need to find a rapid and worthwhile technique for the in situ detection of the content of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in L. is an ever-increasing problem in the forensic field. Among all the techniques for the detection of cannabinoids, Raman spectroscopy can be identified as the most cost-effective, fast, noninvasive, and nondestructive. In this study, 42 different samples were analyzed using Raman spectroscopy with 1064 nm excitation wavelength. The use of an IR wavelength laser showed the possibility to clearly identify THC and CBD in fresh samples, without any further processing, knocking out the contribution of the fluorescence generated by visible and near-IR sources. The results allow assigning all the Raman features in THC- and CBD-rich natural samples. The multivariate analysis underlines the high reproducibility of the spectra and the possibility to distinguish immediately the Raman spectra of the two cannabinoid species. Furthermore, the ratio between the Raman bands at 1295/1440 and 1623/1663 cm is identified as an immediate test parameter to evaluate the THC content in the samples.

摘要

在法医领域，需要找到一种快速且有价值的技术来原位检测大麻中二氢大麻酚（THC）和大麻二酚（CBD）的含量，这是一个日益增长的问题。在所有用于检测大麻素的技术中，拉曼光谱可以被确定为最具成本效益、快速、非侵入性和非破坏性的技术。在这项研究中，使用 1064nm 激发波长的拉曼光谱对 42 种不同的样品进行了分析。使用红外波长激光表明有可能在新鲜样品中清楚地识别 THC 和 CBD，而无需任何进一步的处理，消除了可见光和近红外源产生的荧光的贡献。结果允许对富含 THC 和 CBD 的天然样品中的所有拉曼特征进行分配。多元分析强调了光谱的高度重现性，以及立即区分两种大麻素物种的拉曼光谱的可能性。此外，1295/1440 和 1623/1663cm 处的拉曼带之间的比值被确定为评估样品中 THC 含量的即时测试参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/d0c5eda90c25/ac2c01629_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/63853b03234c/ac2c01629_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/083fcead47a9/ac2c01629_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/8d7ba33edae5/ac2c01629_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/7a5276d9f7f8/ac2c01629_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/a2d906c27b2b/ac2c01629_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/495e3ec3faef/ac2c01629_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/682c79c50453/ac2c01629_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/4ae09b116a06/ac2c01629_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/bb37bb7f427e/ac2c01629_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/d0c5eda90c25/ac2c01629_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/63853b03234c/ac2c01629_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/083fcead47a9/ac2c01629_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/8d7ba33edae5/ac2c01629_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/7a5276d9f7f8/ac2c01629_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/a2d906c27b2b/ac2c01629_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/495e3ec3faef/ac2c01629_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/682c79c50453/ac2c01629_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/4ae09b116a06/ac2c01629_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/bb37bb7f427e/ac2c01629_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d548/9330313/d0c5eda90c25/ac2c01629_0010.jpg

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