College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
J Agric Food Chem. 2022 Jul 27;70(29):8994-9006. doi: 10.1021/acs.jafc.2c02122. Epub 2022 Jul 18.
In the present study, the different lipidomes between human milk and ruminant milk were compared. The 471, 376, 467, and 87 differential lipids were identified in human versus cow, goat, sheep, and camel groups, respectively. According to multivariate statistical analysis, lipids in human and camel milk were closer but differed from other milk. The distributions of long-chain and polyunsaturated fatty acids of triglycerides (TGs), the proportions of functional TGs (OPO, OPL, and PPO), and many kinds of phospholipids (PLs) (PS, PI, GD, GM3, and Cer) in human milk were similar to those in camel milk. The similar structure of TGs and proportion of PLs in human milk to camel milk might contribute to their similar digestion and bioactivity properties. Camel milk could be considered as a new resource of lipid base for infant formula. Minor PLs should also be considered for designing formula. Our results provide a new sight for humanized lipids in infant formula.
本研究比较了人乳和反刍动物乳之间的不同脂质组。在人乳与牛、山羊、绵羊和骆驼组相比中，分别鉴定出了 471、376、467 和 87 个差异脂质。根据多变量统计分析，人乳和骆驼乳中的脂质更为接近，但与其他乳不同。人乳和骆驼乳中的甘油三酯（TG）中的长链和多不饱和脂肪酸分布、功能性 TG（OPO、OPL 和 PPO）的比例以及多种磷脂（PS、PI、GD、GM3 和 Cer）的分布相似。人乳中 TG 的结构相似，PL 的比例与人乳相似，这可能有助于它们具有相似的消化和生物活性特性。骆驼乳可以被视为婴儿配方奶粉脂质基础的新资源。在设计配方时，也应考虑少量的 PL。我们的结果为人乳配方中的人性化脂质提供了新的视角。
