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家兔中白化基因与血红蛋白β链基因座的连锁

Linkage of albino and hemoglobin beta-chain loci in the rabbit.

作者信息

Sandberg K, Andersson L

出版信息

J Hered. 1987 Mar-Apr;78(2):124-5. doi: 10.1093/oxfordjournals.jhered.a110332.

DOI:10.1093/oxfordjournals.jhered.a110332
PMID:3584936
Abstract

Genetic linkage between the albino (c) and hemoglobin beta-chain (Hb beta) genes in rabbits was demonstrated by means of segregation data from one full-sib family. The map distance was estimated at 9 +/- 6 cM, which is similar to the 8 cM previously estimated between the same pair of loci in both mice and rats. The interspecies conservation of the chromosome segment comprising c and Hb beta thus extends outside the rodent family. Indications that it also may be conserved in man are discussed.

摘要

通过一个全同胞家系的分离数据,证明了兔子中白化病(c)基因与血红蛋白β链(Hbβ)基因之间的遗传连锁。估计图距为9±6厘摩,这与之前在小鼠和大鼠中同一对基因座之间估计的8厘摩相似。因此,包含c和Hbβ的染色体片段在种间的保守性延伸到了啮齿动物家族之外。文中还讨论了其在人类中也可能保守的迹象。

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Linkage of albino and hemoglobin beta-chain loci in the rabbit.家兔中白化基因与血红蛋白β链基因座的连锁
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引用本文的文献

1
The tyrosinase-positive oculocutaneous albinism locus is not linked to the beta-globin locus in man.酪氨酸酶阳性的眼皮肤白化病基因座与人的β-珠蛋白基因座不连锁。
Hum Genet. 1988 May;79(1):89. doi: 10.1007/BF00291719.