Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.
Bull Exp Biol Med. 2022 Jul;173(3):322-325. doi: 10.1007/s10517-022-05542-y. Epub 2022 Jul 19.
In a parallel placebo-controlled study, we examined the effect of repetitive transcranial magnetic stimulation (rTMS) on serum concentrations of cortisol and dehydroepiandrosteron sulfate (DHEAS), and their relationships with clinical symptoms in men and women with Parkinson's disease. A 20-day course of real rTMS reduced the UPDRS and UPDRS III scores in patients with Parkinson's disease in comparison with the basal parameters (before rTMS), regardless of their sex. The level of cortisol did not change in men and women; at the same time, the content of DHEAS in men increased and before rTMS negatively correlated with the UPDRS scores. Sham rTMS had no effects on clinical parameters or hormonal levels. Possible mechanisms of sex-dependent differences in the effect of rTMS on the level of the neurosteroid hormone DHEAS are discussed.
在一项平行安慰剂对照研究中，我们研究了重复经颅磁刺激（rTMS）对皮质醇和硫酸脱氢表雄酮（DHEAS）血清浓度的影响，以及它们与帕金森病男性和女性患者临床症状的关系。20 天的真实 rTMS 疗程可降低帕金森病患者的 UPDRS 和 UPDRS III 评分，与基线参数（rTMS 之前）相比，无论其性别如何。皮质醇水平在男性和女性中均未发生变化；同时，男性的 DHEAS 含量增加，且 rTMS 前与 UPDRS 评分呈负相关。假 rTMS 对临床参数或激素水平没有影响。讨论了 rTMS 对神经甾体激素 DHEAS 水平的影响存在性别依赖性差异的可能机制。
