Gruzelier J H, Nicolaou T, Connolly J F, Peatfield R C, Davies P T, Clifford-Rose F
J Neurol Neurosurg Psychiatry. 1987 Apr;50(4):416-22. doi: 10.1136/jnnp.50.4.416.
Support is provided for a primary neural factor in migraine by studies in autonomic responsiveness to sensory stimuli in relation to the laterality of pain. Migraineurs with consistently lateralised headaches were found in two studies to exhibit extremes of autonomic responsiveness to sensory stimuli during the interictal phase. The direction of responsiveness was predictive of the laterality of pain; left-sided pain was associated with under-responsiveness and fast habituation, right-sided pain with over-responsiveness and slow habituation. Bipolarity in rate of habituation is consistent with a defect in a regulatory mechanism that controls regional cerebral activation such as the diffuse thalamic projection system.
关于疼痛偏侧性的自主神经对感觉刺激的反应性研究为偏头痛的主要神经因素提供了支持。在两项研究中发现，患有持续偏侧性头痛的偏头痛患者在发作间期对感觉刺激表现出自主神经反应性的极端情况。反应性的方向可预测疼痛的偏侧性；左侧疼痛与反应不足和快速习惯化相关，右侧疼痛与反应过度和缓慢习惯化相关。习惯化速率的两极分化与控制区域脑激活的调节机制缺陷一致，如弥漫性丘脑投射系统。
