Olesen J, Larsen B, Lauritzen M
Ann Neurol. 1981 Apr;9(4):344-52. doi: 10.1002/ana.410090406.
Regional cerebral blood flow (rCBF) was measured in 254 areas of a hemisphere with the xenon 133 intraarterial injection method. Six cases of classic migraine were followed from the normal state into the prodromal phase, and in 3 cases further into the headache phase. One patient with common migraine was similarly followed during his only classic attack. The attacks were initiated by focal hyperemia in 3 patients. During prodromes all patients displayed occipitoparietal rCBF reduction (oligemia), but in only 1 case did the reduction approach critical values. Oligemia gradually spread anteriorly in the course of 15 to 45 minutes. In 4 patients a global oligemia was observed. In 4 patients severe headache was present concomitantly with oligemia and with no sign of hyperemia or nonhomogeneous brain perfusion. The normal rCBF increase during cortical activity (hand movement, speech, and similar activities) was impaired in 6 patients. The results indicate that the vasospastic model of the migraine attack is too simplistic.
采用氙133动脉内注射法，对一个半球的254个区域进行了局部脑血流量（rCBF）测量。对6例典型偏头痛患者从正常状态追踪至前驱期，其中3例进一步追踪至头痛期。对1例普通偏头痛患者在其唯一一次典型发作期间进行了类似追踪。3例患者的发作由局部充血引发。在前驱期，所有患者均出现枕顶叶rCBF降低（缺血），但仅1例患者的降低接近临界值。缺血在15至45分钟内逐渐向前扩散。4例患者出现全脑缺血。4例患者在缺血的同时伴有严重头痛，且无充血或脑灌注不均的迹象。6例患者在皮质活动（手部运动、言语及类似活动）期间正常的rCBF增加受到损害。结果表明，偏头痛发作的血管痉挛模型过于简单。
