Nikzad Amir H, Cong Yan, Berretta Sarah, Hänsel Katrin, Cho Sunghye, Pradhan Sameer, Behbehani Leily, DeSouza Danielle D, Liberman Mark Y, Tang Sunny X
Feinstein Institutes for Medical Research, Zucker Hillside Hospital, Department of Psychiatry, Glen Oaks, USA.
Yale University, Department of Laboratory Medicine, New Haven, USA.
Schizophrenia (Heidelb). 2022 Jul 5;8(1):58. doi: 10.1038/s41537-022-00263-7.
Graphical representations of speech generate powerful computational measures related to psychosis. Previous studies have mostly relied on structural relations between words as the basis of graph formation, i.e., connecting each word to the next in a sequence of words. Here, we introduced a method of graph formation grounded in semantic relationships by identifying elements that act upon each other (action relation) and the contents of those actions (predication relation). Speech from picture descriptions and open-ended narrative tasks were collected from a cross-diagnostic group of healthy volunteers and people with psychotic or non-psychotic disorders. Recordings were transcribed and underwent automated language processing, including semantic role labeling to identify action and predication relations. Structural and semantic graph features were computed using static and dynamic (moving-window) techniques. Compared to structural graphs, semantic graphs were more strongly correlated with dimensional psychosis symptoms. Dynamic features also outperformed static features, and samples from picture descriptions yielded larger effect sizes than narrative responses for psychosis diagnoses and symptom dimensions. Overall, semantic graphs captured unique and clinically meaningful information about psychosis and related symptom dimensions. These features, particularly when derived from semi-structured tasks using dynamic measurement, are meaningful additions to the repertoire of computational linguistic methods in psychiatry.
言语的图形表示产生了与精神病相关的强大计算指标。以往的研究大多依赖于单词之间的结构关系作为图形形成的基础,即在单词序列中把每个单词与下一个单词连接起来。在此,我们引入了一种基于语义关系的图形形成方法,通过识别相互作用的元素(动作关系)以及这些动作的内容(述谓关系)。从健康志愿者以及患有精神病或非精神病性障碍的跨诊断组中收集了来自图片描述和开放式叙事任务的言语。对录音进行转录并进行自动语言处理,包括语义角色标注以识别动作和述谓关系。使用静态和动态(移动窗口)技术计算结构和语义图形特征。与结构图相比,语义图与维度性精神病症状的相关性更强。动态特征也优于静态特征,并且对于精神病诊断和症状维度,来自图片描述的样本比叙事反应产生的效应量更大。总体而言,语义图捕捉到了有关精神病和相关症状维度的独特且具有临床意义的信息。这些特征,尤其是当从使用动态测量的半结构化任务中得出时,是对精神病学中计算语言学方法库的有意义补充。