Zahra Moradi, Mostafa Tohidian, Yasaman Hekmatnia, Amin Dalili, Mostafa Sadeghi, Seyed Sina Neshat, Sheida Jamalnia, Elnaz Reihani
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Islamic Azad University of Medical Science, Sari, Mazandaran, Iran.
Galen Med J. 2022 Jul 7;10:1-8. doi: 10.31661/gmj.v10i0.2178. eCollection 2021.
Curcumin, a polyphenolic derivative of Curcuma longa rhizome, has numerous beneficial effects, including antibacterial, anti-inflammatory, antiviral, antioxidant, antifungal, anti-ischemic, anti-cancer, hypoglycemic, nephroprotective, antirheumatic, hepato-protective, and antimutagenic. Curcumin has indicated the capability to exert anti-cancer activity by multifunctional mechanisms, such as induction of apoptosis, inhibition of cancer cell proliferation, cell cycle regulation, chemotherapeutic intestinal absorption, and modification of several cancer cell types signaling pathways. Several studies have shown that curcumin may have protective effects against tumors of the reproductive system. Reproductive system cancers may cause many undesirable physical and, especially, mental disorders. Infertility and its mental consequences, sexual problems, chemotherapy and surgery-related adverse effects, substantial economic burden, and death are the most common complications regarding the cancers of the reproductive system. By modulating several reproductive cancer hallmarks such as signaling pathways, multiple drug resistance, cancer cell growth and proliferation, tumor angiogenesis, and transcription factors, curcumin could be used as a safe, non-toxic, cheap, and easily accessible drug for treating different types of reproductive cancers.
姜黄素是姜黄根茎的多酚衍生物，具有多种有益作用，包括抗菌、抗炎、抗病毒、抗氧化、抗真菌、抗缺血、抗癌、降血糖、肾保护、抗风湿、肝保护和抗诱变。姜黄素已表明能够通过多种机制发挥抗癌活性，如诱导细胞凋亡、抑制癌细胞增殖、细胞周期调控、化疗药物肠道吸收以及改变多种癌细胞类型的信号通路。多项研究表明，姜黄素可能对生殖系统肿瘤具有保护作用。生殖系统癌症可能会导致许多不良的身体状况，尤其是精神障碍。不孕及其精神后果、性问题、化疗和手术相关的不良反应、巨大的经济负担以及死亡是生殖系统癌症最常见的并发症。通过调节多种生殖癌症特征，如信号通路、多药耐药性、癌细胞生长和增殖、肿瘤血管生成以及转录因子，姜黄素可作为一种安全、无毒、廉价且易于获取的药物，用于治疗不同类型的生殖癌症。
