Lu Huan, Ma Lingwei, Zhang Yan, Feng Yanzhi, Zhang Jinjin, Wang Shixuan
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
2National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei 430030, China.
Aging Dis. 2022 Jul 11;13(4):1183-1195. doi: 10.14336/AD.2021.1209.
Ovarian aging leads to menopause, loss of fertility and other disorders in multiple organs, which brings great distress to women. For ethical reasons, it is impossible to use humans as direct study subjects for aging research. Therefore, biomedical researchers have employed different non-human organisms to study ovarian aging, including worms, fruit flies, fishes, amphibians, birds, mice, rats, cavies, rabbits, pigs, sheep, cows, horses, monkeys, and apes. Because each of these model organisms has its own features, multiple factors, such as size, anatomical structure, cost, ease of operation, fertility, generation time, lifespan, and gene heredity, should be carefully considered when selecting a model system to study ovarian aging. An appropriate model organism would help researchers explore the risk factors and elucidate molecular mechanisms underlying declined ovarian functions, which might be conducive to preventing or delaying the ovarian aging process. This article will offer an overview on several currently available and commonly used model organisms for ovarian aging research by comparing their pros and cons. In doing so, we hope to provide useful information for ovarian aging researchers.
卵巢衰老会导致更年期、生育能力丧失以及多个器官出现其他紊乱，给女性带来极大困扰。出于伦理原因，不可能将人类作为衰老研究的直接研究对象。因此，生物医学研究人员采用了不同的非人类生物体来研究卵巢衰老，包括蠕虫、果蝇、鱼类、两栖动物、鸟类、小鼠、大鼠、豚鼠、兔子、猪、绵羊、奶牛、马、猴子和猿类。由于这些模式生物各自具有特点，在选择用于研究卵巢衰老的模型系统时，应仔细考虑多个因素，如大小、解剖结构、成本、操作简便性、生育能力、世代时间、寿命以及基因遗传等。合适的模式生物将有助于研究人员探索危险因素并阐明卵巢功能衰退的分子机制，这可能有助于预防或延缓卵巢衰老过程。本文将通过比较几种目前可用且常用的用于卵巢衰老研究的模式生物的优缺点，对其进行概述。通过这样做，我们希望为卵巢衰老研究人员提供有用信息。
