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衰老的卵巢依靠着巨大的多核细胞。

The aging ovary stands on the shoulders of giant multinucleated cells.

作者信息

Ahmed Avery A, Pangas Stephanie A

机构信息

Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States of America.

Graduate Program in Development, Disease Models & Therapeutics, Baylor College of Medicine, Houston, Texas, United States of America.

出版信息

PLoS Biol. 2025 Jun 24;23(6):e3003216. doi: 10.1371/journal.pbio.3003216. eCollection 2025 Jun.

DOI:10.1371/journal.pbio.3003216
PMID:40554744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12187170/
Abstract

Reproductive aging is associated with declining fertility and increasing inflammation, though these events are not well understood. An exciting new study in PLOS Biology utilizes cutting-edge technologies to characterize the role of multinucleated giant cells in ovarian aging.

摘要

生殖衰老与生育能力下降和炎症增加有关，尽管这些现象尚未得到充分了解。《公共科学图书馆·生物学》上一项令人兴奋的新研究利用前沿技术来描述多核巨细胞在卵巢衰老中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc13/12187170/9478e097a35e/pbio.3003216.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc13/12187170/9478e097a35e/pbio.3003216.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc13/12187170/9478e097a35e/pbio.3003216.g001.jpg

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1
The aging ovary stands on the shoulders of giant multinucleated cells.衰老的卵巢依靠着巨大的多核细胞。
PLoS Biol. 2025 Jun 24;23(6):e3003216. doi: 10.1371/journal.pbio.3003216. eCollection 2025 Jun.
2
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.多核巨细胞是卵巢衰老的标志，具有独特的免疫和降解相关分子特征。
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本文引用的文献

1
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.多核巨细胞是卵巢衰老的标志，具有独特的免疫和降解相关分子特征。
PLoS Biol. 2025 Jun 23;23(6):e3003204. doi: 10.1371/journal.pbio.3003204. eCollection 2025 Jun.
2
Current Animal Model Systems for Ovarian Aging Research.当前用于卵巢衰老研究的动物模型系统
Aging Dis. 2022 Jul 11;13(4):1183-1195. doi: 10.14336/AD.2021.1209.
3
Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary.
通过靶向去除小鼠卵巢中的纤维性胶原，延长了雌性生殖寿命。
Sci Adv. 2022 Jun 17;8(24):eabn4564. doi: 10.1126/sciadv.abn4564.
4
Multinucleated giant cell phenotype in response to stimulation.多核巨细胞表型对刺激的反应。
Immunobiology. 2020 May;225(3):151952. doi: 10.1016/j.imbio.2020.151952. Epub 2020 May 5.
5
An Overview of the Derivation and Function of Multinucleated Giant Cells and Their Role in Pathologic Processes.多核巨细胞的发生、功能及其在病理过程中的作用概述。
Am J Pathol. 2019 Jun;189(6):1145-1158. doi: 10.1016/j.ajpath.2019.02.006. Epub 2019 Mar 27.
6
Reproductive age-associated fibrosis in the stroma of the mammalian ovary.哺乳动物卵巢基质中与生殖年龄相关的纤维化
Reproduction. 2016 Sep;152(3):245-260. doi: 10.1530/REP-16-0129.
7
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.慢性炎症（炎症衰老）及其对与年龄相关疾病的潜在贡献。
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9. doi: 10.1093/gerona/glu057.
8
Ovarian aging: mechanisms and clinical consequences.卵巢衰老：机制与临床后果
Endocr Rev. 2009 Aug;30(5):465-93. doi: 10.1210/er.2009-0006. Epub 2009 Jul 9.