Department of General Surgery, University of Hitit Erol Olçok Training and Research Hospital, Corum, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Jul;26(13):4671-4676. doi: 10.26355/eurrev_202207_29191.
Since both breast carcinogenesis and the triglyceride glucose index (TyG) are associated with metabolic syndrome, this study aims at focussing on the TyG index in the breast control group to investigate risk factors causing breast cancer. The predictive value of triglyceride glucose score in predicting breast cancer was investigated.
Patients with a pathological diagnosis of cancer and patients with benign breast lesions who were operated on between May 2018 and December 2021 were included in the study. Patients were divided into two groups: those with Breast Cancer (BC) and those with benign breast lesions. The predictive value of the TyG in predicting breast cancer was investigated. The mean standard deviation (SD) or median values with a 25-75 percent interquartile range (IQR) were used to represent the distribution of continuous data. The Student's t-test was used to evaluate parametric values, and the Mann-Whitney U test was used to analyze non-parametric values. The Chi-square test was used to see if categorical variables could be compared. The optimal cut-off points for the TyG value had been determined using receiver operating curve (ROC) analysis. Cut-off points that are optimal for the TyG value were determined using receiver operating curve (ROC) analysis.
The patients in the study had a median age of 51 [IQR (25-75) = 44-62]. Of the 510 patients who had been operated for a breast lesion, 13 were male and 499 were female. While the median glucose value of the patients was 97 [IQR (25-75) = 89-109-9], the median triglyceride value was 155 [IQR (25-75): 86-159]. When glucose and triglyceride values were examined, group I seemed to have significantly lower values (p<0.001, p=0.001, respectively). The mass size was larger in group 2 (p<0.001). In addition, ln TyG was statistically higher in the malignant group (p<0.001). Receiver operating characteristic curves were obtained for TyG levels in BC diagnosis. (AUC = 0.606, standard error 0.025, p<0.001; 95% CI = 0.556-0.655). The cut-off value for TyG was 8,628. The sensitivity of this value was 57.5% and the specificity was 42.6%.
In this study, we investigated the predictive effect of the TyG index in distinguishing benign and malignant lesions of the breast and concluded that the TyG index can be used to differentiate BC in patients with BC.
由于乳腺癌的发生和甘油三酯葡萄糖指数（TyG）均与代谢综合征有关，因此本研究旨在关注乳腺对照组的 TyG 指数，以研究导致乳腺癌的危险因素。探讨了甘油三酯葡萄糖评分在预测乳腺癌中的预测价值。
纳入 2018 年 5 月至 2021 年 12 月期间接受手术治疗的癌症病理诊断患者和良性乳腺病变患者。将患者分为两组：乳腺癌（BC）组和良性乳腺病变组。探讨 TyG 对预测乳腺癌的预测价值。使用均数标准差（SD）或中位数（25-75 百分位数范围）表示连续数据的分布。采用 Student's t 检验评估参数值，采用 Mann-Whitney U 检验分析非参数值。采用卡方检验比较分类变量。采用受试者工作特征曲线（ROC）分析确定 TyG 值的最佳截断点。
本研究患者的中位年龄为 51 岁[四分位距（IQR）（25-75）= 44-62]。510 例乳腺病变患者中，男性 13 例，女性 499 例。患者的中位血糖值为 97 [IQR（25-75）= 89-109-9]，中位甘油三酯值为 155 [IQR（25-75）：86-159]。当检查血糖和甘油三酯值时，第 I 组似乎明显较低（p<0.001，p=0.001）。第 2 组的肿块大小更大（p<0.001）。此外，恶性组的 lnTyG 明显更高（p<0.001）。获得了 TyG 水平在 BC 诊断中的受试者工作特征曲线。（AUC=0.606，标准误差 0.025，p<0.001；95%CI=0.556-0.655）。TyG 的截断值为 8628。该值的灵敏度为 57.5%，特异性为 42.6%。
在这项研究中，我们调查了 TyG 指数在鉴别乳腺良恶性病变中的预测效果，并得出结论，TyG 指数可用于鉴别 BC 患者的 BC。
