Shi Haimeng, Guo Feifei, Zheng Kang, Li Rong, Zhou Huaijun
Department of Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing University Medical School, Nanjing, China.
Department of Anesthesiology, Nanjing Pukou District Hospital of Chinese Medicine, Nanjing, China.
Int J Gynaecol Obstet. 2024 Jan;164(1):298-304. doi: 10.1002/ijgo.15038. Epub 2023 Aug 9.
We analyzed the association between the triglyceride-glucose index (TyG index) and incident endometrial carcinogenesis, aiming to determine whether the TyG index is a promising predictive biomarker for endometrial carcinoma (EC).
In this retrospective cohort study, multiple logistic regression analysis was performed to evaluate the relationship between TyG index and EC incidence and progression. The receiver operating characteristic (ROC) curve was used to calculate the area under the curve (AUC), as well as the cut-off value of the TyG index for EC incidence.
The TyG index was significantly higher in patients with EC or endometrial atypical hyperplasia (EAH) than in those with normal endometrium (P < 0.001). A continuous rise was observed in the incidence of EC and EAH among the tertiles of the TyG index (P < 0.001). The multiple logistic regression analysis revealed that the TyG index was associated with EC and EAH risk after adjusting for potential confounding factors (EAH: odds ratio [OR] 2.54, 95% confidence interval [CI] 1.33-4.85, P = 0.005; EC: OR 2.65, 95% CI 1.60-4.41, P < 0.001). Moreover, high TyG index was positively associated with advanced pathological stage (OR 2.14, 95% CI 1.32-3.47, P = 0.002) and poorer differentiation (OR 2.53, 95% CI 1.36-4.72, P = 0.004).
The TyG index might be a promising biomarker for endometrial carcinogenesis. Subjects with a higher TyG index should be aware of the risk of EC incidence and progression.
我们分析了甘油三酯-葡萄糖指数（TyG指数）与子宫内膜癌发生之间的关联，旨在确定TyG指数是否为子宫内膜癌（EC）的一种有前景的预测生物标志物。
在这项回顾性队列研究中，进行了多因素逻辑回归分析，以评估TyG指数与EC发病率及进展之间的关系。采用受试者工作特征（ROC）曲线计算曲线下面积（AUC）以及EC发病的TyG指数临界值。
EC或子宫内膜非典型增生（EAH）患者的TyG指数显著高于子宫内膜正常的患者（P<0.001）。在TyG指数三分位数中，EC和EAH的发病率呈持续上升趋势（P<0.001）。多因素逻辑回归分析显示，在调整潜在混杂因素后，TyG指数与EAH和EC风险相关（EAH：比值比[OR]2.54，95%置信区间[CI]1.33-4.85，P=0.005；EC：OR 2.65，95%CI 1.60-4.41，P<0.001）。此外，高TyG指数与病理分期较晚（OR 2.14，95%CI 1.32-3.47，P=0.002）及分化较差（OR 2.53，95%CI 1.36-4.72，P=0.004）呈正相关。
TyG指数可能是子宫内膜癌发生的一种有前景的生物标志物。TyG指数较高的个体应注意EC发病及进展的风险。
