Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Mol Med Rep. 2022 Sep;26(3). doi: 10.3892/mmr.2022.12796. Epub 2022 Jul 20.
Prostate cancer (PCa) has long been a major public health problem affecting men worldwide. Even with treatment, it can develop into castration‑resistant PCa. With the continuous advancement in epigenetics, researchers have explored N6‑methyladenosine (mA) in search of a more effective and lasting treatment for PCa. mA is widely distributed in mammalian cells and influences various aspects of mRNA metabolism. Recently, it has been associated with the development or suppression of various types of cancer, including PCa. This review summarizes the recent findings on mA regulation and its functions and mechanisms in cells, focusing on the various functional proteins operating within mA in PCa cells. Moreover, the potential clinical value of exploiting mA modification as an early diagnostic marker in PCa diagnosis and therapeutics was discussed. mA may also be used as an indicator to evaluate treatment outcome and prognosis.
前列腺癌（PCa）一直是一个全球性的重大公共卫生问题，影响着全世界的男性。即使经过治疗，它也可能发展为去势抵抗性 PCa。随着表观遗传学的不断发展，研究人员一直在探索 N6-甲基腺苷（mA），以期为 PCa 找到更有效和持久的治疗方法。mA 广泛分布于哺乳动物细胞中，影响 mRNA 代谢的各个方面。最近，它与各种类型癌症的发展或抑制有关，包括 PCa。本综述总结了 mA 调控及其在细胞中的功能和机制的最新发现，重点介绍了在 PCa 细胞中发挥作用的各种功能蛋白。此外，还讨论了利用 mA 修饰作为 PCa 诊断和治疗的早期诊断标志物的潜在临床价值。mA 也可以用作评估治疗效果和预后的指标。
