Department of Excellence of Biomedical Science and Public Health, Faculty of medicine, University "Politecnica delle Marche", Ancona, Italy.
National Centre on Addiction and Doping, National Institute of Health, Rome, Italy.
Clin Ter. 2022 Jul-Aug;173(4):304-305. doi: 10.7417/CT.2022.2438.
The continuous emergence of New Psychoactive Substances enter-ing the illegal markets poses always new challenges to forensic and clinical toxicology laboratories facing the lack of analytical methods capable of determining the newer parent compounds and eventual metabolites. More than 50 new molecules have been reported by the European Monitoring Centre for Drugs and Drug Addiction only in 2021, further expanding the panel of target analytes. However, the implementation of new detection methodologies may not be viable due to time constraints and inadequate resources. To this concern, the updatable analytical screening methods constitute a powerful tool for pharmacotoxicological laboratories investigating both non biological seizure materials and conventional and non conventional matrices coming from intoxications and fatalities of drugs consumers.
新精神活性物质不断涌入非法市场，这给法医和临床毒理学实验室带来了新的挑战，因为这些实验室缺乏能够检测到更新的母体化合物和潜在代谢物的分析方法。仅在 2021 年，欧洲毒品和毒瘾监测中心就报告了 50 多种新分子，进一步扩大了目标分析物的范围。然而，由于时间限制和资源不足，实施新的检测方法可能并不可行。为此，可更新的分析筛选方法是对药理毒理学实验室进行研究的有力工具，这些实验室研究的对象包括非生物性癫痫材料以及来自吸毒者中毒和死亡的常规和非常规基质。
