Beyoğlu Abdullah, Kurutaş Ergül Belge, Karaküçük Yalçın, Çömez Ayşegül, Meşen Ali
Department of Ophthalmology, Faculty of Medicine, Sutcu Imam Universty, Kahramanmaras, Turkey.
Department of Biochemistry, Faculty of Medicine, Sutcu Imam Universty, Kahramanmaras, Turkey.
Arq Bras Oftalmol. 2022 Jul 18;87(1):0311. doi: 10.5935/0004-2749.2021-0311. eCollection 2022.
This study aimed to determine the effect of serum G receptor-mediated protein-1 levels on the development of retinopathy in patients with diabetes in comparison with healthy individuals.
The study enrolled patients with diabetic retinopathy (Group 1), patients without diabetic retinopathy (Group 2), and healthy individuals (Group 3). Levels of serum progesterone, serum G receptor-mediated protein-1, estradiol, oxidant/antioxidants, and thyroid-releasing hormones were analyzed and compared among the groups. Post-hoc analysis was performed to compare the subgroups in which significant differences were found.
Groups 1, 2, and 3 each included 40 patients. A significant difference was found among all groups in terms of serum G receptor-mediated protein-1, oxidant/antioxidant, and estradiol levels (p<0.01), but no significant difference was found in terms of thyroid-releasing hormone or progesterone (p=0.496, p=0.220, respectively). In the post-hoc analysis of the groups with significant differences, another significant difference was found among all groups for serum G receptor-mediated protein-1 and oxidant/antioxidant levels (p<0.05). Serum G receptor-mediated protein-1 and oxidant levels were positively correlated, whereas serum G receptor-mediated protein-1 and antioxidant levels were negatively correlated (r=0.622/p<0.01, r=0.453/p<0.01, r=0.460/p<0.01, respectively). The multiple regression analysis showed that increased levels of serum G receptor-mediated protein-1 may help prevent diabetic retinopathy.
Serum G receptor-mediated protein-1 levels, which were the highest in the diabetic retinopathy Group, increased as the oxidant/antioxidant balance changed in favor of oxidative stress. This appears to be a defense mechanism for preventing neuronal damage.
本研究旨在确定与健康个体相比，血清G受体介导蛋白-1水平对糖尿病患者视网膜病变发展的影响。
该研究纳入了糖尿病视网膜病变患者（第1组）、无糖尿病视网膜病变患者（第2组）和健康个体（第3组）。分析并比较了各组血清孕酮、血清G受体介导蛋白-1、雌二醇、氧化剂/抗氧化剂及甲状腺释放激素的水平。进行事后分析以比较发现有显著差异的亚组。
第1、2、3组各有40例患者。所有组在血清G受体介导蛋白-1、氧化剂/抗氧化剂及雌二醇水平方面存在显著差异（p<0.01），但在甲状腺释放激素或孕酮方面未发现显著差异（分别为p=0.496，p=0.220）。在对有显著差异的组进行事后分析时，所有组在血清G受体介导蛋白-1和氧化剂/抗氧化剂水平方面又发现了显著差异（p<0.05）。血清G受体介导蛋白-1与氧化剂水平呈正相关，而血清G受体介导蛋白-与抗氧化剂水平呈负相关（分别为r=0.622/p<0.01，r=0.453/p<0.01，r=0.460/p<0.01）。多元回归分析表明，血清G受体介导蛋白-1水平升高可能有助于预防糖尿病视网膜病变。
血清G受体介导蛋白-1水平在糖尿病视网膜病变组中最高，随着氧化剂/抗氧化剂平衡向有利于氧化应激的方向变化而升高。这似乎是一种预防神经元损伤的防御机制。
