Rema M, Mohan V, Bhaskar A, Shanmugasundaram K R
M.V. Diabetes Specialities Centre, Madras.
Indian J Ophthalmol. 1995 Mar;43(1):17-21.
The role of oxidant stress in the causation of chronic tissue damage is being increasingly recognized. Oxidant stress is usually countered by abundant supply of antioxidants. If concomitant antioxidant deficiency occurs, oxidant stress may produce tissue damage. We took up a study on antioxidant status in non-insulin dependent diabetes mellitus (NIDDM) patients with and without retinopathy and compared them with a control non-diabetic group. The levels of superoxide dismutase (SOD) were significantly reduced in all diabetic patients, i.e., those with and without retinopathy. However, the lowest levels were found in the diabetic patients with retinopathy. Vitamin E and vitamin C levels were also markedly lower in the diabetic patients. There was a paradoxical rise in the catalase and glutathione peroxidase (GPx) in the diabetic patients with retinopathy. This may be a compensatory mechanism by the body to prevent tissue damage by increasing the levels of the two alternative antioxidant enzymes.
氧化应激在慢性组织损伤病因中的作用日益受到认可。氧化应激通常会被大量的抗氧化剂供应所抵消。如果同时出现抗氧化剂缺乏，氧化应激可能会导致组织损伤。我们对患有和未患有视网膜病变的非胰岛素依赖型糖尿病（NIDDM）患者的抗氧化状态进行了研究，并将他们与非糖尿病对照组进行了比较。所有糖尿病患者，即患有和未患有视网膜病变的患者，超氧化物歧化酶（SOD）水平均显著降低。然而，患有视网膜病变的糖尿病患者中SOD水平最低。糖尿病患者的维生素E和维生素C水平也明显较低。患有视网膜病变的糖尿病患者的过氧化氢酶和谷胱甘肽过氧化物酶（GPx）出现了反常升高。这可能是身体的一种补偿机制，通过增加这两种替代抗氧化酶的水平来防止组织损伤。
