Liu Danjie, Peng Renjun, Chen Zhongmin, Yu Huijie, Wang Sinian, Dong Suhe, Li Wei, Shao Wen, Dai Jing, Li Fengsheng, Jiang Qisheng, Sun Wanjun
The Postgraduate Training Base of Jinzhou Medical University (The PLA Rocket Force Characteristic Medical Center), Beijing, China.
Department of Nuclear Radiation Injury and Monitoring, The PLA Rocket Force Characteristic Medical Center, Beijing, China.
Dose Response. 2022 Jul 13;20(3):15593258221113791. doi: 10.1177/15593258221113791. eCollection 2022 Jul-Sep.
Radiation-induced intestinal injury (RIII) restricts the therapeutic efficacy of radiotherapy in abdominal or pelvic malignancies. Also, intestinal injury is a major cause of death following exposure to high doses of radiation in nuclear accidents. No safe and effective prophylactics or therapeutics for RIII are currently available. Here, we reported that the apigenin, a natural dietary flavone, prolonged the survival in c57 mice after lethal irradiation. Apigenin pretreatment brought about accelerated restoration of crypt-villus structure, including enhanced regenerated crypts, more differentiated epithelium cells, and increased villus length. In addition, intestinal crypt cells in the apigenin-treated group exhibited more proliferation and less apoptosis. Furthermore, apigenin increased the expression of Nrf2 and its downstream target gene HO-1, and decreased oxidative stress after irradiation. In conclusion, our findings demonstrate the radioprotective efficacy of apigenin. Apigenin has the potential to be used as a radioprotectant in cancer therapy and nuclear accidents.
辐射诱导的肠道损伤（RIII）限制了放疗在腹部或盆腔恶性肿瘤治疗中的疗效。此外，肠道损伤是核事故中高剂量辐射暴露后死亡的主要原因。目前尚无针对RIII的安全有效的预防或治疗方法。在此，我们报道了芹菜素，一种天然膳食黄酮，可延长致死性照射后C57小鼠的生存期。芹菜素预处理可加速隐窝-绒毛结构的恢复，包括增强再生隐窝、更多分化的上皮细胞以及增加绒毛长度。此外，芹菜素处理组的肠道隐窝细胞增殖更多且凋亡更少。此外，芹菜素增加了Nrf2及其下游靶基因HO-1的表达，并降低了照射后的氧化应激。总之，我们的研究结果证明了芹菜素的辐射防护功效。芹菜素有可能用作癌症治疗和核事故中的辐射防护剂。
