Yoon A-Rum, Wadhwa Renu, Kaul Sunil C, Yun Chae-Ok
Department of Bioengineering, College of Engineering, Hanyang University, Seoul, South Korea.
Institute of Nano Science and Technology (INST), Hanyang University, Seoul, South Korea.
Front Cell Dev Biol. 2022 Jun 29;10:914540. doi: 10.3389/fcell.2022.914540. eCollection 2022.
Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of the disease and identify novel targets for the development of better treatment strategies. Mortalin is a member of the heat shock 70 kDa protein family. It is enriched in several types of cancer and contributes to carcinogenesis in various ways, including inactivation of the tumor suppressor p53, deregulation of apoptosis, induction of epithelial-mesenchymal transition, and enhancement of cancer stemness. It has been studied extensively as a therapeutic target for cancer treatment, and several types of anti-mortalin molecules have been discovered that effectively suppress the tumor cell growth. In this review, we 1) provide a comprehensive sketch of the role of mortalin in tumor biology; 2) discuss various anti-mortalin molecules, including natural compounds, synthetic small molecules, peptides, antibodies, and nucleic acids, that have shown potential for cancer treatment in laboratory studies; and 3) provide future perspectives in cancer treatment.
癌症是全球主要死因之一，2020年导致近1000万人死亡。因此，癌症治疗是一个优先研究领域，旨在探索该疾病的生物学特性并确定新的靶点，以开发更好的治疗策略。mortalin是热休克70 kDa蛋白家族的成员。它在多种类型的癌症中富集，并以多种方式促进致癌作用，包括肿瘤抑制因子p53的失活、细胞凋亡失调、上皮-间质转化的诱导以及癌症干性的增强。作为癌症治疗的靶点，它已被广泛研究，并且已经发现了几种类型的抗mortalin分子，它们能有效抑制肿瘤细胞生长。在这篇综述中，我们1）全面概述了mortalin在肿瘤生物学中的作用；2）讨论了各种抗mortalin分子，包括天然化合物、合成小分子、肽、抗体和核酸，它们在实验室研究中已显示出癌症治疗潜力；3）提供了癌症治疗的未来展望。
