Khusnurrokhman Gemilang, Wati Farah Fatma
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Ann Med Surg (Lond). 2022 Jun 19;79:104022. doi: 10.1016/j.amsu.2022.104022. eCollection 2022 Jul.
Tumor-promoting inflammation is an inflammation that occurs because tumor cells cause necrosis of healthy cells which releases cell contents into the environment, triggering the release of proinflammatory mediators. There are intrinsic and outside factors of tumor-promoting inflammation. Intrinsic factors are genetically related, while extrinsic factors are due to mediators and inflammatory cells. The primary inflammatory mediators in the tumorigenesis process include NF-kB, STAT3, HIF-1, and TNF-α. in contrast, the inflammatory cells that play a role are TAM, a collection of tumor-associated leukocytes. Bacteria is also one of the extrinsic factors that can cause tumors because of the chronic inflammation it causes.
肿瘤促进性炎症是一种由于肿瘤细胞导致健康细胞坏死，从而将细胞内容物释放到周围环境中，进而触发促炎介质释放而发生的炎症。肿瘤促进性炎症存在内在因素和外在因素。内在因素与基因相关，而外在因素则归因于介质和炎症细胞。肿瘤发生过程中的主要炎症介质包括核因子-κB、信号转导和转录激活因子3、缺氧诱导因子-1和肿瘤坏死因子-α。相比之下，发挥作用的炎症细胞是肿瘤相关巨噬细胞，它是一群肿瘤相关白细胞。细菌也是能够因引发慢性炎症而导致肿瘤的外在因素之一。
