帕金森病伴轻度认知障碍患者独特的胆汁酸特征
Distinct Bile Acid Signature in Parkinson's Disease With Mild Cognitive Impairment.
作者信息
Nie Kun, Li Yanyi, Zhang Jiahui, Gao Yuyuan, Qiu Yihui, Gan Rong, Zhang Yuhu, Wang Lijuan
机构信息
Department of Neurology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Shantou University Medical College, Shantou, China.
出版信息
Front Neurol. 2022 Jul 4;13:897867. doi: 10.3389/fneur.2022.897867. eCollection 2022.
BACKGROUNDS
Bile acid (BA) plays a crucial role in various neurodegenerative diseases, including Parkinson's disease (PD). However, no clinical evidence supports BA's potential role in patients with PD with mild cognitive impairment (PD-MCI).
OBJECTIVES
This study aimed at investigating the differential BA profile between patients with PD-MCI and those with normal cognitive function (PD-NC).
METHODS
Ultra-high performance liquid chromatography-MS/MS was applied for BA quantitation. After between-group differences of the BA profile were addressed, orthogonal projections to latent structures-discriminant analysis (OPLS-DA) and the area under the receiver-operating-characteristic curve (AUC-ROC) were implemented for further verification.
RESULTS
Lower levels of chenodeoxycholic acid (CDCA), cholic acid (CA), and ursodeoxycholic acid (UDCA) were significantly associated with PD-MCI ( < 0.01 for both; VIP ≈ 2.67, 1.66, and 1.26, respectively). AUC-ROC were 78.1, 74.2, and 74.5% for CDCA, CA, and UDCA, respectively.
CONCLUSION
CA, CDCA, and UDCA might be distinct BA signatures for patients with PD-MCI.
背景
胆汁酸（BA）在包括帕金森病（PD）在内的各种神经退行性疾病中起关键作用。然而，尚无临床证据支持BA在轻度认知障碍帕金森病（PD-MCI）患者中的潜在作用。
目的
本研究旨在调查PD-MCI患者与认知功能正常的帕金森病患者（PD-NC）之间胆汁酸谱的差异。
方法
采用超高效液相色谱-串联质谱法对胆汁酸进行定量分析。在分析胆汁酸谱的组间差异后，采用正交投影到潜在结构判别分析（OPLS-DA）和受试者工作特征曲线下面积（AUC-ROC）进行进一步验证。
结果
鹅去氧胆酸（CDCA）、胆酸（CA）和熊去氧胆酸（UDCA）水平降低与PD-MCI显著相关（两者均P<0.01；VIP分别约为2.67、1.66和1.26）。CDCA、CA和UDCA的AUC-ROC分别为78.1%、74.2%和74.5%。
结论
CA、CDCA和UDCA可能是PD-MCI患者独特的胆汁酸特征。
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