Liu Yishen, Li Yang, Koo Seyoung, Sun Yao, Liu Yixuan, Liu Xing, Pan Yanna, Zhang Zhiyun, Du Mingxia, Lu Siyu, Qiao Xue, Gao Jianfeng, Wang Xiaobo, Deng Zixin, Meng Xianli, Xiao Yuling, Kim Jong Seung, Hong Xuechuan
State Key Laboratory of Virology, College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa 850000, China.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
Chem Rev. 2022 Jan 12;122(1):209-268. doi: 10.1021/acs.chemrev.1c00553. Epub 2021 Oct 19.
imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types of inorganic/organic fluorophores that can be used for noninvasive NIR-IIa/IIb imaging (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence and deeper tissue penetration. This review provides an overview of the reports published to date on the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. First, we summarize the design concepts of the up-to-date functional NIR-IIa/IIb biomaterials, in the order of single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), and organic fluorophores (OFs). Then, these novel imaging modalities and versatile biomedical applications brought by these superior fluorescent properties are reviewed. Finally, challenges and perspectives for future clinical translation, aiming at boosting the clinical application progress of NIR-IIa and NIR-IIb imaging technology are highlighted.
在第二近红外窗口（NIR-II，1000 - 1700纳米）进行成像，使我们能够深入观察活体，为生物医学研究和临床应用带来了绝佳机遇。最近，跨学科研究热潮涌现，聚焦于开发多种无机/有机荧光团，用于无创NIR-IIa/IIb成像（NIR-IIa，1300 - 1400纳米；NIR-IIb，1500 - 1700纳米），具有近零组织自发荧光和更深的组织穿透性。本综述概述了迄今为止发表的有关无机/有机NIR-IIa/IIb荧光团的设计、性质、分子成像和诊疗学的报告。首先，我们按单壁碳纳米管（SWCNTs）、量子点（QDs）、稀土掺杂纳米颗粒（RENPs）和有机荧光团（OFs）的顺序总结了最新功能性NIR-IIa/IIb生物材料的设计概念。然后，回顾了这些优异荧光特性带来的新型成像模式和多样生物医学应用。最后，强调了旨在推动NIR-IIa和NIR-IIb成像技术临床应用进展的未来临床转化面临的挑战和前景。
