胡知道吗？枯草芽孢杆菌 HBsu 是 DNA 复制起始所必需的。
HU Knew? Bacillus subtilis HBsu Is Required for DNA Replication Initiation.
机构信息
Centre for Bacterial Cell Biology, Newcastle Universitygrid.1006.7, Newcastle upon Tyne, United Kingdom.
出版信息
J Bacteriol. 2022 Aug 16;204(8):e0015122. doi: 10.1128/jb.00151-22. Epub 2022 Jul 11.
Abstract
The prokaryotic nucleoid-associated protein (NAP) HU is both highly conserved and ubiquitous. Deletion of HU causes pleiotropic phenotypes, making it difficult to uncover the critical functions of HU within a bacterial cell. In their recent work, Karaboja and Wang (J Bacteriol 204:e00119-22, 2022, https://doi.org/10.1128/JB.00119-22) show that one essential function of Bacillus subtilis HU (HBsu) is to drive the DnaA-dependent initiation of DNA replication at the chromosome origin. We discuss the possible roles of HBsu in replication initiation and other essential cellular functions.
摘要
原核核小体相关蛋白 (NAP) HU 高度保守且普遍存在。HU 的缺失会导致多种表型，这使得很难揭示 HU 在细菌细胞内的关键功能。在他们最近的工作中，Karaboja 和 Wang（J Bacteriol 204:e00119-22, 2022, https://doi.org/10.1128/JB.00119-22）表明枯草芽孢杆菌 HU（HBsu）的一个基本功能是驱动 DnaA 依赖性染色体复制原点起始。我们讨论了 HBsu 在复制起始和其他必需细胞功能中的可能作用。
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