来自丹参的细胞毒性二萜醌类化合物。
Cytotoxic diterpene quinones from Salvia tebesana Bunge.
机构信息
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Fitoterapia. 2018 Jul;128:97-101. doi: 10.1016/j.fitote.2018.05.005. Epub 2018 May 14.
A phytochemical investigation of the root extracts of Salvia tebesana Bunge led to the isolation of two new diterpenoids, tebesinone A (1) and tebesinone B (2), along with two known compounds, aegyptinone A (3) and aegyptinone B (4). The structures were established by spectroscopic analysis including 1D and 2D NMR and HRESIMS. The cytotoxic activities of the crude extracts and isolated compounds were evaluated against MCF-7, B16F10, PC-3 and C26 human cancer cell lines, in which compounds 2 and 3 showed significant cytotoxic activities (IC 2.1-10.3 μM).
从藏丹参根的提取物中分离得到了两种新的二萜化合物，即 tebesinone A（1）和 tebesinone B（2），以及两种已知的化合物，aegyptinone A（3）和 aegyptinone B（4）。通过包括 1D 和 2D NMR 以及 HRESIMS 在内的光谱分析确定了这些化合物的结构。对粗提取物和分离得到的化合物进行了 MCF-7、B16F10、PC-3 和 C26 人癌细胞系的细胞毒性活性评价，其中化合物 2 和 3 表现出显著的细胞毒性活性（IC 2.1-10.3μM）。
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