Department of Molecular Biotechnology and Microbiology, University of Debrecen, Egyetem Tér 1, 4032 Debrecen, Hungary.
Res Microbiol. 2022 Oct-Dec;173(8):103969. doi: 10.1016/j.resmic.2022.103969. Epub 2022 Jul 19.
The growth of 14 Aspergillus strains belonging to nine species was studied under combinatorial deferriprone - HO (iron-chelation - oxidative) stress. When deferriprone pretreated mycelia were subjected to even a weak oxidative stress, the growth inhibitory effect of iron-chelation stress was enhanced in 10 out of 14 strains. In contrast, oxidative stress pretreatment of conidia increased their deferriprone tolerance in 10 strains. Applying iron-chelators as antifungal agent or adjuvant can enhance the efficiency of the combinatorial iron withdrawal - oxidative stress strategy of our immune system and may reduce the survival of conidia escaped from the oxidative attack of pulmonary macrophages.
研究了属于九个种的 14 株曲霉在组合脱铁普隆 - HO（铁螯合 - 氧化）应激下的生长情况。当用脱铁普隆预处理菌丝体后，即使受到较弱的氧化应激，14 株中的 10 株的铁螯合应激生长抑制作用增强。相比之下，10 株中的 10 株的孢子经氧化应激预处理后，增加了对脱铁普隆的耐受性。将铁螯合剂作为抗真菌剂或佐剂应用，可提高我们免疫系统组合铁剥夺 - 氧化应激策略的效率，并可能降低从肺巨噬细胞氧化攻击中逃脱的孢子的存活率。
