Kassab Institute of Orthopedics, Tunis, Tunisia.
Pan Afr Med J. 2022 Apr 25;41:331. doi: 10.11604/pamj.2022.41.331.31312. eCollection 2022.
sleep disorders, closely related to any chronic pain process, are frequent among patients with rheumatic diseases, mainly ankylosing spondylitis (AS). Our study aimed to determine the association between sleep disturbances and the inflammatory process in pain in AS patients compared with lower back pain (LBP) patients. We have additionally examined factors associated with sleep disorders among AS patients.
we conducted a cross-sectional study among AS patients. Sociodemographic data, patient reported outcomes and disease characteristics were recorded. Sleep was assessed using the medical outcomes study sleep scale measure (MOS-SS). For psychological assessment, Beck anxiety (BAI) and depression index (BDI) was used. A multivariate logistic regression was performed to identify factors associated with sleep disorders.
the study included 50 patients with AS and 40 patients with low back pain. The most common affected domains among AS patients were inadequacy, sleep disturbance, and daily somnolence. The MOS-SS index was significantly higher in the AS group than in the control group (p<0.001). Sleep disorder was associated with age, female gender, analphabetism, patient-reported outcomes (all p<0.05), but was not associated with profession, comorbidities and smoking habits. In multivariate analysis, factors associated with sleep disruption were the duration of morning stiffness (MS), disease activity, bath ankylosing spondylitis metrology index (BASMI), ASQol, as well as anxiety and depression (odds ratio: 5.4(CI 95% 1.6-18.3), 9.9 (CI95%1.1-86); 6 (CI95%1.1-32); 13 (CI 95% 1.4-143.8); 15.7 (CI 95% 2.6-94.3); 14 (CI 95% 2-105.7) respectively, p<0.05 for each).
our study highlighted the importance of sleep disorders among patients with AS with a predilection for inadequacy, sleep disturbance, and daily somnolence. Factors associated with sleep disruption were high disease activity, a longer duration of MS, an altered function and quality of life as well as anxiety and depression.
睡眠障碍与任何慢性疼痛过程密切相关，在风湿性疾病患者中很常见，主要是强直性脊柱炎（AS）。我们的研究旨在确定与疼痛相关的睡眠障碍与 AS 患者炎症过程之间的关系，与下腰痛（LBP）患者进行比较。我们还检查了 AS 患者睡眠障碍相关的因素。
我们对 AS 患者进行了横断面研究。记录了社会人口统计学数据、患者报告的结果和疾病特征。使用医学结局研究睡眠量表（MOS-SS）评估睡眠。为了进行心理评估，使用贝克焦虑量表（BAI）和抑郁指数（BDI）。进行了多变量逻辑回归分析，以确定与睡眠障碍相关的因素。
研究包括 50 名 AS 患者和 40 名下腰痛患者。AS 患者中最常见的受影响领域是不适当、睡眠障碍和日常嗜睡。AS 组的 MOS-SS 指数明显高于对照组（p<0.001）。睡眠障碍与年龄、女性、文盲、患者报告的结果（均 p<0.05）相关，但与职业、合并症和吸烟习惯无关。在多变量分析中，与睡眠中断相关的因素是晨僵（MS）持续时间、疾病活动度、bath 强直性脊柱炎计量指数（BASMI）、ASQol 以及焦虑和抑郁（比值比：5.4（95%CI 1.6-18.3）、9.9（95%CI1.1-86）；6（95%CI1.1-32）；13（95%CI 1.4-143.8）；15.7（95%CI 95% 2.6-94.3）；14（95%CI 95% 2-105.7），p<0.05）。
我们的研究强调了 AS 患者睡眠障碍的重要性，其特点是不适、睡眠障碍和日常嗜睡。与睡眠中断相关的因素是疾病活动度高、MS 持续时间较长、功能和生活质量改变以及焦虑和抑郁。
