非洲孕妇血小板减少症：系统评价和荟萃分析。

Thrombocytopenia among pregnant women in Africa: a systematic review and meta-analysis.

机构信息

Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

Pan Afr Med J. 2022 Apr 26;41:334. doi: 10.11604/pamj.2022.41.334.30175. eCollection 2022.

DOI:10.11604/pamj.2022.41.334.30175

PMID:35865846

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9268328/

Abstract

INTRODUCTION

thrombocytopenia is a common hematological disorder during pregnancy next to anemia. Pregnant women with thrombocytopenia have complications of excessive bleeding during or after childbirth, cesarean section incision site oozing, stillbirth and neonatal thrombocytopenia. Findings on the magnitude of thrombocytopenia among pregnant women were inconsistent. Therefore, this review aimed to estimate the pooled prevalence of thrombocytopenia among pregnant women in Africa.

METHODS

this systematic review and meta-analysis were performed based on PRISMA guidelines. The databases (PubMed, PubMed Central, Hinari, Science Direct, Pop line, Google Scholar, and African Journals Online) were searched to identify relevant studies. Data were analyzed using STATA 11 statistical software. A random-effect model was fitted to estimate the pooled prevalence of thrombocytopenia. I test statistics were done to test the heterogeneity of included studies. Funnel plots analysis and Egger weighted regression tests were done to detect publication bias.

RESULTS

of the total 1,517 articles retrieved, 15 articles which involved 8,380 pregnant women were eligible for meta-analysis. The overall pooled prevalence of thrombocytopenia among pregnant women in Africa was 10.23% (95% confidence interval (CI): 7.44, 13.02%). Its level of severity showed that, 77.95% (I=43.1%), 15.62% (I=53.4%), and 5.60 (I=0.0%) of pregnant women had mild, moderate and severe thrombocytopenia, respectively. The highest prevalence of thrombocytopenia was occurred in the third trimester of pregnancy (54.05% (95% CI: 29.48, 78.61)).

CONCLUSION

this systematic review and meta-analysis showed that the pooled prevalence of thrombocytopenia among pregnant women in Africa was found to be relatively higher compared with the globe. Therefore, routine screening and follow-up programs are needed to identify pregnant women with thrombocytopenia and provide them with the necessary interventions.

摘要

简介

血小板减少症是妊娠期间除贫血外常见的血液学疾病。血小板减少症孕妇在分娩期间或之后、剖宫产切口部位渗血、死产和新生儿血小板减少症方面存在并发症。关于孕妇血小板减少症严重程度的研究结果并不一致。因此，本综述旨在估计非洲孕妇血小板减少症的患病率。

方法

本系统评价和荟萃分析基于 PRISMA 指南进行。检索了数据库（PubMed、PubMed Central、Hinari、Science Direct、Pop line、Google Scholar 和 African Journals Online）以识别相关研究。使用 STATA 11 统计软件分析数据。采用随机效应模型估计血小板减少症的总患病率。采用 I 检验统计量检验纳入研究的异质性。采用漏斗图分析和 Egger 加权回归检验检测发表偏倚。

结果

在总共检索到的 1517 篇文章中，有 15 篇文章涉及 8380 名孕妇，符合荟萃分析的条件。非洲孕妇血小板减少症的总患病率为 10.23%（95%置信区间（CI）：7.44，13.02%）。其严重程度显示，77.95%（I=43.1%）、15.62%（I=53.4%）和 5.60%（I=0.0%）的孕妇分别有轻度、中度和重度血小板减少症。血小板减少症的最高患病率发生在妊娠晚期（54.05%（95% CI：29.48，78.61%））。