Division of Obstetrics and Gynaecology, University of Western Australia, Perth, WA, Australia.
School of Pharmacy and Biomedical Science, Curtin University, Perth, WA, Australia.
PLoS One. 2022 Jul 22;17(7):e0272064. doi: 10.1371/journal.pone.0272064. eCollection 2022.
Worldwide, over 8 million children and adults are conceived following assisted reproductive technologies (ART), and their long-term health is of consequential public health interest. The objective of this paper is to describe the Growing up Healthy Study (GUHS) cohort in detail, publicise it and invite collaboration. Combining the data collected in the GUHS with other cohorts or databases will improve the much-needed knowledge about the effects of ART, and allow for better understanding of the long-term health outcomes of offspring conceived after ART. The GUHS cohort is a prospective observational study of adolescents and young adults conceived after assisted reproductive technologies (ART). It was established to determine if the long-term health of offspring conceived by ART differs from that of the general population. This was investigated by comparing a substantial number of health parameters to those of a representative population of offspring conceived without ART. The n = 303 GUHS participants were born between 1991-2001 in the two fertility clinics operating at the time in Perth, Western Australia, and undertook assessments at ages 14, 17 and 20, replicating the pre-defined study protocols from the reference cohort-the Raine Study. Participants were comprehensively phenotyped through detailed questionnaires, anthropometry, biochemical analyses, as well as age-specific assessments (asthma, atopy, cardiometabolic health, body composition, mental health, thyroid function, epigenetics and vision). To date the GUHS cohort has been used to study the methylation, cardiometabolic, and thyroid profiles, as well as respiratory and mental health. To summarise, the GUHS cohort provides a valuable addition to the limited knowledge of the long-term health outcomes of ART-conceived offspring.
全世界有超过 800 万儿童和成年人是通过辅助生殖技术（ART）受孕的，他们的长期健康是具有重要公共卫生意义的。本文的目的是详细描述正在进行的“健康成长研究（GUHS）”队列，宣传该队列并邀请合作。将 GUHS 队列的数据与其他队列或数据库相结合，将提高人们对 ART 影响的必要性认识，并有助于更好地了解 ART 后受孕后代的长期健康结果。GUHS 队列是一项对辅助生殖技术（ART）受孕的青少年和年轻成年人进行的前瞻性观察研究。该研究旨在确定通过 ART 受孕的后代的长期健康是否与普通人群不同。通过将大量健康参数与未经 ART 受孕的代表性人群的参数进行比较来实现这一目标。GUHS 队列的 303 名参与者于 1991-2001 年在澳大利亚珀斯的两家生育诊所出生，分别在 14、17 和 20 岁时接受评估，复制了参考队列（Raine 研究）预先定义的研究方案。通过详细的问卷、人体测量学、生化分析以及特定年龄的评估（哮喘、过敏、心血管代谢健康、身体成分、心理健康、甲状腺功能、表观遗传学和视力）对参与者进行全面表型分析。迄今为止，GUHS 队列已被用于研究甲基化、心血管代谢和甲状腺特征以及呼吸和心理健康。总之，GUHS 队列为有限的 ART 受孕后代长期健康结果知识提供了有价值的补充。
