Ilmuratova Sevara, Manzhuova Lyazzat, Bazarbayeva Aigul, Lokshin Vyacheslav, Nurgaliyeva Zhanar, Kussainova Farida
Department of Science and Consulting, Kazakhstan Medical University KSPH, Almaty, Republic of Kazakhstan.
Department of Science and Postgraduate Education, Scientific Center of Pediatrics and Children's Surgery, Almaty, Republic of Kazakhstan.
Qatar Med J. 2025 Jan 20;2025(1):9. doi: 10.5339/qmj.2025.9. eCollection 2025.
Reproductive technologies are used more widely today than ever before. This increase in the use of assisted reproductive technology (ART) is directly related to sociodemographic conditions that result in delayed childbirth among age groups with lower fertility. Infertility affects 17% of married couples, and in some countries 6% of children are born with in vitro fertilization (IVF). In this context, the aspect of the influence of reproductive technologies on hormonal indicators of offspring in relation to anthropometric data remains insufficiently examined. The purpose of this cohort study is to compare the hormonal panel and anthropometric data of ART-conceived children with the corresponding data of children conceived naturally.
Biochemical tests are used to determine the amount of free triiodothyronine (T3) and total thyroxine (T4), somatotropin, insulin, insulin-like growth factor, glucose, potassium, and sodium cations in blood samples from the experimental and control groups.
The results indicate that the use of assisted reproductive technologies neither altered the endocrine panel of the thyroid gland, nor affected other biochemical parameters. Variations in technologies - classical IVF, fresh or frozen embryo transfer, intracytoplasmic sperm injection - also did not affect the quantitative value of the above indicators. Artificial insemination also had no effect on puberty (in both boys and girls). Children born naturally had a greater body weight (3,453 vs 3,160 g, < 0.001) and height (53 vs 51 cm, = 0.002). ART children had significantly higher median free tbl3 levels (3.65 vs 3.48 mU/L, = 0.002) and potassium levels (4.8 vs 4.7 mmol/L, = 0.013), although within the reference ranges. Glucose levels were also higher in ART children (median 4.45 vs 4.29 mg/dl, = 0.01).
Several relationships between biochemical and anthropometric indicators were identified: the correlation between body weight and blood levels of insulin-like growth factor was statistically significant, positive, and weak. The tbl3 level in the experimental group was found to be statistically significant and directly proportional to body height, and insulin content was inversely proportional to body weight. The data obtained make it possible to verify the safety of using a different range of reproductive technologies.
如今，生殖技术的应用比以往任何时候都更为广泛。辅助生殖技术（ART）使用的增加与社会人口统计学状况直接相关，这些状况导致生育力较低的年龄组生育延迟。不孕症影响17%的已婚夫妇，在一些国家，6%的儿童通过体外受精（IVF）出生。在这种背景下，生殖技术对后代激素指标与人体测量数据关系方面的影响仍未得到充分研究。这项队列研究的目的是比较ART受孕儿童的激素指标和人体测量数据与自然受孕儿童的相应数据。
使用生化测试来测定实验组和对照组血样中游离三碘甲状腺原氨酸（T3）、总甲状腺素（T4）、生长激素、胰岛素、胰岛素样生长因子、葡萄糖、钾和钠阳离子的含量。
结果表明，辅助生殖技术的使用既未改变甲状腺的内分泌指标，也未影响其他生化参数。技术差异——经典IVF、新鲜或冷冻胚胎移植、卵胞浆内单精子注射——也未影响上述指标的定量值。人工授精对青春期（男孩和女孩）也没有影响。自然出生的儿童体重更重（3453克对3160克，<0.001），身高更高（53厘米对51厘米，=0.002）。ART儿童的游离tbl3中位数水平显著更高（3.65对3.48 mU/L，=0.002），钾水平也更高（4.8对4.7 mmol/L，=0.013），尽管在参考范围内。ART儿童的葡萄糖水平也更高（中位数4.45对4.29 mg/dl，=0.01）。
确定了生化指标和人体测量指标之间的几种关系：体重与胰岛素样生长因子血液水平之间的相关性具有统计学意义、呈正相关且较弱。发现实验组中的tbl3水平具有统计学意义，且与身高成正比，胰岛素含量与体重成反比。所获得的数据使得验证使用不同范围生殖技术的安全性成为可能。
