Department of Biophysics, Panjab University, Chandigarh, India.
Biol Trace Elem Res. 2023 Jun;201(6):2843-2853. doi: 10.1007/s12011-022-03366-5. Epub 2022 Jul 22.
α-Tocotrienol is one of the major constituents of palm oil. It is a well-known antioxidant and cholesterol-lowering neuroprotectant. To prevent the initiation of Alzheimer's like symptoms, much attention has been shifted to the major role played by antioxidants. Previous epidemiological reports correlate the increasing incidence of developing Alzheimer's disease (AD), to the aluminum (Al) content in drinking water. Al, being a ubiquitous element, has a long history of being particularly reactive towards multiple aspects of neurobiology. So, the current study examines the effect of Al-induced behavioral, biochemical, and histopathological changes in rat brain; and the ameliorative effect of palm oil in reducing the resulting neurotoxicity. The experimental design consisted of 4 groups: control group which received rodent chow diet and water ad libitum; Al group received aluminum lactate (50 mg/kg bw); Al + palm oil group was administered with Al (50 mg/kg bw) and palm oil (60 mg/kg bw); and palm oil group received palm oil (60 mg/kg bw). Al was given by oral gavage once daily for 6 weeks and palm oil was administered intraperitoneally. After 6 weeks of supplementation, Al + palm oil group showed significantly lower malondialdehyde (MDA) content, but higher superoxide dismutase (SOD), catalase (CAT), GST, and GPx activity as compared to Al group. Al group has significantly higher level of MDA content, but lower SOD, CAT, GST, and GPx activity as compared to control group. In conclusion, this study suggested that palm oil was effective in preventing the Al-induced brain damage in rats.
α-生育三烯酚是棕榈油的主要成分之一。它是一种众所周知的抗氧化剂和降低胆固醇的神经保护剂。为了预防阿尔茨海默病样症状的发生，人们越来越关注抗氧化剂的主要作用。以前的流行病学报告表明，饮用水中铝（Al）含量的增加与阿尔茨海默病（AD）发病率的增加有关。Al 是一种无处不在的元素，长期以来一直对神经生物学的多个方面表现出特别高的反应性。因此，目前的研究检查了 Al 诱导的大鼠大脑行为、生化和组织病理学变化的影响，以及棕榈油在减少由此产生的神经毒性方面的改善作用。实验设计包括 4 组：对照组接受啮齿动物饲料饮食和自由饮水；Al 组接受乳酸铝（50mg/kg bw）；Al+棕榈油组给予 Al（50mg/kg bw）和棕榈油（60mg/kg bw）；棕榈油组给予棕榈油（60mg/kg bw）。Al 通过口服灌胃每天一次，持续 6 周，棕榈油通过腹腔内给药。补充 6 周后，与 Al 组相比，Al+棕榈油组的丙二醛（MDA）含量显著降低，但超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽 S-转移酶（GST）和谷胱甘肽过氧化物酶（GPx）活性更高。Al 组的 MDA 含量明显更高，但 SOD、CAT、GST 和 GPx 活性均低于对照组。总之，本研究表明棕榈油可有效预防大鼠的 Al 诱导性脑损伤。
