Anatomy Department, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Physiology department, Faculty of Medicine, University of Medical Science, Mashhad, Iran.
Sci Rep. 2017 Oct 30;7(1):14365. doi: 10.1038/s41598-017-14765-3.
Spinal cord injury (SCI) occurs following different types of crushes. External and internal outcomes of SCI are including paralysis, cavity, and cyst formation. Effects of dietary derived antioxidants, such as palm vitamin E on central nervous system (CNS) encourage researchers to focus on the potential therapeutic benefits of antioxidant supplements. In the present study, experiments were carried out to evaluate the neuro-protective effect of the palm vitamin E on locomotor function and morphological damages induced SCI. Seventy-two male rats (Sprague-Dawley) were randomly divided into four groups: sham (laminectomy); control (supplemented with the palm vitamin E at a dose of 100 mg/kg/day); untreated-SCI (partial crush, 30-33% for 20 sec); treated-SCI (partial crush, 30-33% for 20 sec supplemented with the palm vitamin E at a dose of 100 mg/kg/day). The treatment with the palm vitamin E significantly improved the hind limb locomotor function, reduced the histopathological changes and the morphological damage in the spinal cord. Also, the palm vitamin E indicated a statistically significant decrease in the oxidative damage indicators, malondialdehyde (MDA) level and glutathione peroxidase (GPx) activity in the treated-SCI compared to the untreated-SCI.
脊髓损伤 (SCI) 是由不同类型的挤压造成的。SCI 的外部和内部结果包括瘫痪、空洞和囊肿形成。膳食来源的抗氧化剂，如棕榈维生素 E 对中枢神经系统 (CNS) 的影响，促使研究人员关注抗氧化补充剂的潜在治疗益处。在本研究中，进行了实验以评估棕榈维生素 E 对 SCI 诱导的运动功能和形态损伤的神经保护作用。72 只雄性大鼠 (Sprague-Dawley) 被随机分为四组：假手术组（椎板切除术）；对照组（补充棕榈维生素 E，剂量为 100mg/kg/天）；未治疗-SCI 组（部分挤压，30-33%挤压 20 秒）；治疗-SCI 组（部分挤压，30-33%挤压 20 秒，补充棕榈维生素 E，剂量为 100mg/kg/天）。棕榈维生素 E 的治疗显著改善了后肢运动功能，减少了脊髓的组织病理学变化和形态损伤。此外，与未治疗-SCI 相比，棕榈维生素 E 表明在治疗-SCI 中氧化损伤指标丙二醛 (MDA) 水平和谷胱甘肽过氧化物酶 (GPx) 活性有统计学意义的降低。
