Ren Yan, Bao Shuang, Jia Yuan, Sun Xiao-Li, Cao Xiang-Xin, Bai Xiao-Ying, Tian Jun-Sheng, Yang Hong
Department of Psychiatry, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Taiyuan, China.
Biotherapy Lab, Shanxi Bethune Hospital, Taiyuan, China.
Front Psychiatry. 2020 Dec 16;11:569612. doi: 10.3389/fpsyt.2020.569612. eCollection 2020.
Bipolar disorder (BD) is a common and debilitating mental disorder. Bipolar depression is the main episode of BD. Furthermore, there are no objective biomarkers available for diagnosing the disorder. In this research, a Nuclear Magnetic Resonance (NMR) spectroscopy based on a metabonomics technique was used to analyze serum samples from 37 patients with bipolar depression and 48 healthy control participants to determine potential biomarkers for bipolar depression. In total, seven different metabolites were identified that could effectively distinguish patients from healthy controls. The metabolites indicated that disturbances of amino acid and energy metabolisms might be involved in the pathogenesis of BD. Finally, a panel consisting of four potential biomarkers (lactate, trimethylamine oxide, N-acetyl glycoprotein, and α-glucose) was identified, which showed a higher combined diagnostic ability with an area under the curve of 0.893. Our findings may contribute to the development of an objective method for diagnosing bipolar depression.
双相情感障碍（BD）是一种常见且使人衰弱的精神障碍。双相抑郁是BD的主要发作类型。此外，目前尚无用于诊断该疾病的客观生物标志物。在本研究中，基于代谢组学技术的核磁共振（NMR）光谱法被用于分析37例双相抑郁患者和48名健康对照参与者的血清样本，以确定双相抑郁的潜在生物标志物。总共鉴定出七种不同的代谢物，它们能够有效地区分患者与健康对照。这些代谢物表明氨基酸和能量代谢紊乱可能参与了BD的发病机制。最后，确定了一个由四种潜在生物标志物（乳酸、氧化三甲胺、N-乙酰糖蛋白和α-葡萄糖）组成的组合，其联合诊断能力更高，曲线下面积为0.893。我们的研究结果可能有助于开发一种诊断双相抑郁的客观方法。
