Department of Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Health Qual Life Outcomes. 2022 Jul 23;20(1):112. doi: 10.1186/s12955-022-02018-5.
To study development trajectories to 34 years of age of health-related quality of life (HRQoL) and subjective health complaints in extremely preterm (EP) born subjects with and without disability, and to compare with term-born controls.
A Norwegian longitudinal population-based cohort of subjects born in 1982-85 at gestational age ≤ 28 weeks or with birth weight ≤ 1000 g and matched term-born controls completed the Norwegian version of the Short Form Health Survey-36 at ages 24 and 34 and the Health Behaviour in School-aged Children-Symptom Checklist at ages 17, 24 and 34 years. Data were analysed by unadjusted and adjusted mixed effects analyses with time by subject group as interaction term.
A total of 35/49 (73%) surviving EP-born and 36/46 (78%) term-born controls participated at this third follow-up. EP-born subjects with severe disability reported clinical significant lower mean score in all domains compared to the term-born controls. Healthy EP-born subjects reported significantly lower mean scores for vitality, role emotional and mental health, and significantly higher mean score for total and psychological health complaints compared to term-born controls. There were no significant interactions with age regarding HRQoL and somatic health complaints, while there were significant differences in psychological health complaints; the EP-born scored higher at age 24 and lower at age 34.
EP-born adults at age 34 reported inferior HRQoL versus term-born peers, especially in the mental health domains, indicating that the negative differences observed at 24 years remained unchanged.
研究健康相关生活质量（HRQoL）和主观健康抱怨的发展轨迹，直至 34 岁，研究对象为极早产儿（EP）和无残疾的足月出生对照，以及与足月出生对照进行比较。
挪威一项基于人群的纵向队列研究，纳入了 1982-1985 年出生的 EP 婴儿，胎龄≤28 周或出生体重≤1000g，并与足月出生的对照组相匹配。参与者在 24 岁和 34 岁时完成了挪威版的健康调查简表-36（Short Form Health Survey-36），在 17 岁、24 岁和 34 岁时完成了青少年健康行为症状检查表（Health Behaviour in School-aged Children-Symptom Checklist）。采用未经调整和调整后的混合效应分析，以时间和受试者组作为交互项进行分析。
共有 35/49（73%）幸存的 EP 出生和 36/46（78%）足月出生的对照组参加了第三次随访。患有严重残疾的 EP 出生者在所有领域的平均得分都明显低于足月出生的对照组。健康的 EP 出生者报告说，活力、情感角色和心理健康的平均得分明显较低，而总健康和心理健康抱怨的平均得分明显较高，与足月出生的对照组相比。在 HRQoL 和躯体健康抱怨方面，与年龄没有显著的交互作用，但在心理健康抱怨方面存在显著差异；EP 出生者在 24 岁时得分较高，在 34 岁时得分较低。
34 岁的 EP 出生者报告的 HRQoL 低于足月出生的同龄人，特别是在心理健康领域，这表明在 24 岁时观察到的负面差异没有改变。
