Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Acta Paediatr. 2024 Jun;113(6):1288-1297. doi: 10.1111/apa.17146. Epub 2024 Feb 14.
Investigate potential long-term cohort influences on health-related quality of life (HRQoL) in adults born extremely preterm (EP) during the 1980-90s, in view of advancements in neonatal care within that timeframe.
Two cohorts of EP-born adults (82-85 cohort and 91-92 cohort) enrolling matched term controls, were compared. Participants were assessed at 18 years and again in their mid-twenties using the Child Health Questionnaire Children Form-87 (CHQ-CF87) and the Short Form Health Survey (SF-36).
At 18 years, 77 (90%) EP-born and 75 (93%) term controls had data, followed by 67 (78%) EP-born and 66 (82%) term controls in their mid-twenties. At 18 years, there were no differences across the birth decades, and EP-born and term-born reported relatively similar HRQoL scores. In the mid-twenties, birth decade did also not significantly impact HRQoL scores, although the EP-born 82-85 cohort scored numerically poorer than the 91-92 cohort in three domains. Term controls scored similarly across birth decade in all domains. Regarding influence from neonatal factors, postnatal corticosteroids had a negative impact in some domains.
No significant differences in HRQoL were observed between EP-born adults from the 82-85 cohort versus the 91-92 cohort, although the EP-born 82-85 cohort tended to score poorer in their mid-twenties.
鉴于该时期新生儿护理的进步，研究 20 世纪 80 至 90 年代期间出生的极早产儿（EP）的成年人健康相关生活质量（HRQoL）的潜在长期队列影响。
比较了两个 EP 出生的成年人队列（82-85 队列和 91-92 队列）和匹配的足月对照者。参与者在 18 岁和二十多岁中期分别使用儿童健康问卷儿童形式-87（CHQ-CF87）和简短健康调查（SF-36）进行评估。
在 18 岁时，77 名（90%）EP 出生者和 75 名（93%）足月对照者有数据，其次是 67 名（78%）EP 出生者和 66 名（82%）足月对照者在二十多岁中期。在 18 岁时，不同的出生年代之间没有差异，并且 EP 出生者和足月出生者报告的 HRQoL 评分相对相似。在二十多岁中期，出生年代也没有显著影响 HRQoL 评分，尽管 EP 出生的 82-85 队列在三个领域的得分略低于 91-92 队列。足月对照者在所有领域的得分在出生年代之间相似。关于新生儿因素的影响，产后皮质类固醇在某些领域有负面影响。
在 HRQoL 方面，82-85 队列与 91-92 队列的 EP 出生成年人之间没有观察到显著差异，尽管 EP 出生的 82-85 队列在二十多岁中期的得分较差。
