Faculdade de Nutrição, Universidade Federal de Alagoas, Campus AC Simões - Av Lourival Melo Mota, s / n, Cidade Universitária - Maceió - AL, CEP: 57072-900, Maceió, Alagoas, Brazil.
Faculdade de Nutrição, Universidade Federal de Alagoas, Campus AC Simões - Av Lourival Melo Mota, s / n, Cidade Universitária - Maceió - AL, CEP: 57072-900, Maceió, Alagoas, Brazil.
Clin Nutr ESPEN. 2022 Aug;50:264-269. doi: 10.1016/j.clnesp.2022.05.005. Epub 2022 May 18.
BACKGROUND & AIMS: This study aimed to evaluate the efficacy of "red propolis" supplementation in the frequency of acute respiratory infections incidence in stunted preschool children. We hypothesized that the "red" propolis supplementation is effective in the reduce frequency of acute respiratory complications in stunted children.
This is a non-randomized, pair-matched clinical trial with 70 children, ranging from 1 to 5 years old, followed for 1 year, which were paired into two groups according to age, sex, and stunting classification. The children were in the day hospital regimen of CREN and received 5 meals/day and an additional 8 ml of honey or honey with "red propolis" in a 3% dilution. The children had access to nutritional, psychological, dental, and physician care. Respiratory complications were recorded in a pre-existing protocol of the institution by the same pediatrician, who was blind for the children's allocation. Anthropometric measurements and biochemical tests such as hemogram, IGF-1, and immunoglobulin E, G, M were conducted.
The most prevalent symptoms were coughing, runny nose, nasal congestion and wheezing. The use of "red propolis" did not decrease the frequency of infections between the control and propolis groups, respectively (2 [1-7] vs 3 [1-7], p = 0.10), which was within the estimated by the Pan American Health Organization. There were no differences between groups in anthropometric and biochemical parameters.
Supplementation with "red propolis" did not reduce the number of infections in stunted children over 1 year. Possibly, the dilution percentage (3%) may have been insufficient to allow effective action. The protocol of published in the Brazilian Registry of Clinical Trials (http://www.ensaiosclinicos.gov.br/rg/RBR-4n7j6h).
本研究旨在评估“红蜂胶”补充剂对生长迟缓学龄前儿童急性呼吸道感染发生率的疗效。我们假设“红”蜂胶补充剂可有效降低生长迟缓儿童急性呼吸道并发症的发生频率。
这是一项非随机、配对的临床试验，纳入了 70 名年龄在 1 至 5 岁之间的儿童，随访时间为 1 年。根据年龄、性别和生长迟缓程度将儿童配对分为两组。儿童在 CREN 日间医院接受治疗，每天接受 5 餐，并额外服用 8 毫升蜂蜜或 3%稀释的蜂蜜加“红蜂胶”。儿童还可获得营养、心理、牙科和医生护理。由同一名儿科医生根据机构预先制定的方案记录呼吸道并发症，该医生对儿童的分组情况不知情。进行了体格测量和血液生化检查，如血常规、IGF-1 和免疫球蛋白 E、G、M。
最常见的症状是咳嗽、流鼻涕、鼻塞和喘息。与对照组相比，使用“红蜂胶”并没有降低感染的发生率（分别为 2[1-7]和 3[1-7]，p=0.10），这在泛美卫生组织的估计范围内。两组在体格测量和生化参数方面无差异。
在 1 年以上的生长迟缓儿童中，补充“红蜂胶”并没有减少感染的发生。可能是由于稀释比例（3%）不足，无法发挥有效作用。本研究方案已在巴西临床试验注册中心（http://www.ensaiosclinicos.gov.br/rg/RBR-4n7j6h）注册。
