Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, China.
Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangzhou, China.
J Affect Disord. 2022 Oct 1;314:253-258. doi: 10.1016/j.jad.2022.07.021. Epub 2022 Jul 22.
Depressed patients suffered from severe psychological distress even after the first COVID-19 outbreak was initially controlled. The longitudinal changes and associations among stress and other psychological problems during this period remained unknown. In this study we investigated stress symptoms and the longitudinal impact of stress symptoms on other psychological symptoms in depressed patients after the first COVID-19 outbreak was initially controlled.
A total of 5241 depressed patients at the outpatients of 56 hospitals across mainland China were recruited from May 18 to June 18, 2020. Five months later, 2113 of them responded again. Demographic characteristics were collected and psychological symptoms were evaluated at baseline and the follow-up. The longitudinal associations between stress symptoms at baseline and the changes of other psychological problems were assessed using Poisson regression.
The prevalence of stress symptoms, depressive symptoms, anxiety symptoms and insomnia symptoms declined over time. Having stress symptoms at baseline was positively associated with the new occurrences of depressive symptoms, anxiety symptoms and insomnia symptoms (range, adjusted RRs 1.69-1.81).
The sampling method and the high dropout rate are the major limitations. Additionally, the mental conditions of the participants were not obtained, which may lead to unavoidable bias.
The prevalence of stress symptoms declined over time after the first COVID-19 outbreak was initially controlled. We found that having stress symptoms at baseline was a predictor for the new occurrences of depressive symptoms, anxiety symptoms and insomnia symptoms.
即使在首次 COVID-19 爆发得到初步控制后，抑郁患者仍遭受严重的心理困扰。在此期间，压力和其他心理问题的纵向变化及其相关性尚不清楚。在这项研究中，我们调查了首次 COVID-19 爆发得到初步控制后抑郁患者的压力症状以及压力症状对其他心理症状的纵向影响。
2020 年 5 月 18 日至 6 月 18 日，我们从中国大陆 56 家医院的 5241 名抑郁患者中招募了参与者。5 个月后，其中 2113 名患者再次做出回应。我们在基线和随访时收集了人口统计学特征和心理症状。使用泊松回归评估基线时的压力症状与其他心理问题变化之间的纵向关联。
压力症状、抑郁症状、焦虑症状和失眠症状的患病率随时间推移而下降。基线时存在压力症状与新发抑郁症状、焦虑症状和失眠症状呈正相关（范围，调整后的 RR 为 1.69-1.81）。
抽样方法和高辍学率是主要限制。此外，参与者的心理状况未被获取，这可能导致不可避免的偏倚。
首次 COVID-19 爆发得到初步控制后，压力症状的患病率随时间推移而下降。我们发现基线时存在压力症状是新发抑郁症状、焦虑症状和失眠症状的预测因素。
