Yoshitake Rieko, Nakai Hiroko, Ebina Manato, Kawasaki Kengo, Murosaki Shinji, Hirose Yoshitaka
Research and Development Institute, House Wellness Foods Corp., Itami, Japan.
Front Med (Lausanne). 2022 Jul 6;9:912280. doi: 10.3389/fmed.2022.912280. eCollection 2022.
To determine whether consuming heat-killed L-137 (HK L-137) influences skin functions, we performed a randomized, placebo-controlled, double-blind study in healthy participants who were conscious of dry skin. A total of 80 healthy participants (20 men, 60 women; mean age, 47.3 years) were assigned to receive a tablet containing HK L-137 or a placebo tablet daily for 12 weeks. Every 4 weeks, the skin water content and transepidermal water loss (TEWL) were measured at the forearm and face, and participants completed two skin-related questionnaires, the Dermatology Life Quality Index and a self-evaluation. The HK L-137 group tended to show greater increases from baseline of water content at the forearm and larger decreases of TEWL at the face. The total scores of both questionnaires improved significantly more in the HK L-137 group. Water content and TEWL improved significantly in participants in the HK L-137 group who were above the median age of study participants or had relatively dry skin. These findings suggest that daily HK L-137 intake can improve dry skin, thereby contributing to skin satisfaction.
为了确定食用热灭活的L-137（HK L-137）是否会影响皮肤功能，我们对有皮肤干燥问题的健康参与者进行了一项随机、安慰剂对照、双盲研究。总共80名健康参与者（20名男性，60名女性；平均年龄47.3岁）被分配为每天服用一片含有HK L-137的片剂或一片安慰剂，持续12周。每4周测量一次前臂和面部的皮肤水分含量和经表皮水分流失（TEWL），参与者完成两份与皮肤相关的问卷，即皮肤病生活质量指数和自我评估。HK L-137组在前臂的水分含量较基线的增加幅度往往更大，在面部的TEWL下降幅度更大。两份问卷的总分在HK L-137组中改善得更为显著。在年龄高于研究参与者中位数年龄或皮肤相对干燥的HK L-137组参与者中，水分含量和TEWL有显著改善。这些发现表明，每日摄入HK L-137可以改善皮肤干燥，从而提高皮肤满意度。
