Hoshino Tomohiro, Yamashita Shin-Ichiro, Suzuki Naoko, Baba Asami, Ogawa Sosuke, Izumi Tatsuya
a R&D Department , ORTHOMEDICO Inc. , Bunkyo-ku , Tokyo , Japan.
b Research & Development Division , Mimozax Co., Ltd. , Hatsukaichi-city Hiroshima , Japan.
Biosci Biotechnol Biochem. 2019 Mar;83(3):538-550. doi: 10.1080/09168451.2018.1547626. Epub 2018 Dec 10.
This study investigated the effects of proanthocyanidins derived from Acacia (Acacia mearnsii) bark extract in healthy Japanese adult subjects experiencing uncomfortable skin symptoms. All subjects were randomly allocated into two groups (n = 33 each) using a computerized random-number generator. The subjects received either Acacia bark extract tablets or placebo for 8 weeks. Evaluations included water content in the stratum corneum, transepidermal water loss (TEWL), Skindex-16, dermatology life quality index (DLQI), visual analog scale for desire to scratch, and blood tests. At 4 weeks, the symptom/feeling score of DLQI, subjective symptoms related to uncomfortable skin, and the desire to scratch were significantly reduced in the intervention group than in the placebo group. At 8 weeks, the intervention group exhibited significantly lower TEWL on facial skin than that in the placebo group. In conclusion, the intake of Acacia bark extract tablets reduced TEWL and improved dry and uncomfortable skin.
本研究调查了相思树（黑荆树）树皮提取物中原花青素对有皮肤不适症状的健康日本成年受试者的影响。使用计算机随机数生成器将所有受试者随机分为两组（每组n = 33）。受试者接受相思树树皮提取物片或安慰剂治疗8周。评估指标包括角质层含水量、经表皮水分流失（TEWL）、Skindex-16、皮肤病生活质量指数（DLQI）、搔抓欲望视觉模拟量表以及血液检查。在4周时，干预组的DLQI症状/感受评分、与皮肤不适相关的主观症状以及搔抓欲望均比安慰剂组显著降低。在8周时，干预组面部皮肤的TEWL显著低于安慰剂组。总之，摄入相思树树皮提取物片可降低TEWL并改善皮肤干燥和不适状况。
